Document Detail

Eye movements in amyotrophic lateral sclerosis and its mimics: a review with illustrative cases.
MedLine Citation:
PMID:  21097546     Owner:  NLM     Status:  MEDLINE    
Abnormal eye movements are increasingly recognised in patients with amyotrophic lateral sclerosis (ALS) and, when they occur, may provide insights into the pattern and pathogenesis of the disease process. In patients with disorders that mimic ALS, abnormal eye movements may point to the correct diagnosis. In both of these circumstances, systematic examination of eye movements and interpretation of the findings with reference to modern concepts of their neural substrate will aid diagnosis and suggest pathogenesis. Here, key points with illustrative case histories and eye movement records are highlighted.
Colette Donaghy; Matthew J Thurtell; Erik P Pioro; J Mark Gibson; R John Leigh
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-11-19
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  82     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  110-6     Citation Subset:  IM    
Department of Neurology, Royal Victoria Hospital, Belfast, UK.
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MeSH Terms
Amyotrophic Lateral Sclerosis / complications,  diagnosis,  physiopathology*
Disease Progression
Eye Movements / physiology*
Fixation, Ocular / physiology
Nystagmus, Pathologic / etiology
Ocular Motility Disorders / diagnosis,  etiology*,  physiopathology
Ophthalmoplegia / etiology
Supranuclear Palsy, Progressive / physiopathology
Grant Support

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