Document Detail


Eye closure related spike and wave discharges: clinical and syndromic associations.
MedLine Citation:
PMID:  10578473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Precipitation of spike and wave (SW) discharges in some epileptic patients by eye closure (EC) has rarely been reported. To disclose the clinical characteristics and classification of syndromes of epileptic patients with SW discharges induced by EC, we investigated 10 patients (1 M, 9 F) showing this peculiar EEG feature. The patients aged between 9-39 years (mean 20.6 +/- 9.058), underwent short-term (1-3.5 hr) video-EEG investigations in order to document the appearance of the SW discharges within 3 seconds of the act of EC, in at least two occasions. Clinical analysis showed that 5 female patients who had the syndrome of juvenile myoclonic epilepsy (JME) had a later onset of epilepsy (13-15 years) than the 3 patients (3 girls) with eyelid myoclonia with absences (EMA) (3-8 years of age at onset). The remaining 2 patients who were diagnosed as childhood absence epilepsy (CAE) and juvenile absence epilepsy (JAE) according to the international classification, did not show photosensitivity on the video-EEG. All but one of the 5 JME patients had experienced myoclonic seizures in intermittent photic stimulation (IPS) at the time of EC, associated with multiple spike and wave discharges. Two of the 3 EMA patients exhibited typical absences with eyelid myoclonia during the act of EC. The high rate of family history of epilepsy in first degree relatives of our patients was an outstanding feature, which could have future implications in research of the genetic basis of epilepsy patients with ECS.
Authors:
B Baykan-Kurt; A Gökyiğit; Y Parman; D Kinay; C Gürses
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical EEG (electroencephalography)     Volume:  30     ISSN:  0009-9155     ISO Abbreviation:  Clin Electroencephalogr     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2000-01-06     Completed Date:  2000-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0236454     Medline TA:  Clin Electroencephalogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  106-10     Citation Subset:  IM    
Affiliation:
University of Istanbul, Istanbul Medical Faculty, Department of Neurology, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Electroencephalography*
Epilepsies, Myoclonic / diagnosis,  physiopathology
Epilepsy, Absence / diagnosis,  physiopathology
Eyelids / physiopathology*
Female
Humans
Male
Myoclonus / physiopathology*
Photic Stimulation
Prospective Studies
Seizures / diagnosis,  etiology,  physiopathology*
Syndrome

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