Document Detail


Eye-blinking rates are slower in infants with iron-deficiency anemia than in nonanemic iron-deficient or iron-sufficient infants.
MedLine Citation:
PMID:  20335633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron deficiency has been shown to impair dopamine functioning in rodent models, but it is challenging to obtain evidence of such effects in human infants. Because spontaneous eye-blink rate may provide a noninvasive assessment of dopamine functioning, we hypothesized that eye-blink rate would be lower in infants with iron-deficiency anemia and would increase with iron therapy. A 4-min eye-blink assessment was conducted for quiet, alert infants sitting on their mother's lap. Data were available for 61 9- to 10-mo-old infants from inner-city Detroit (19 iron-deficient anemic, 23 nonanemic iron-deficient, and 19 nonanemic iron-sufficient). Iron-deficient and iron-sufficient nonanemic groups had similar eye-blink rates (P = 0.90) and were therefore combined. We used Poisson regression based on generalized estimation equation methodology to test for differences between iron-deficient anemic and nonanemic infants in blinks/min and change after 3 mo of iron therapy. Iron-deficient anemic infants had a lower initial eye-blink rate than nonanemic infants (mean +/- SD) (4.0 +/- 1.9 vs. 5.3 +/- 2.8 blinks/min; P = 0.02; effect size = 0.6 SD). At 12 mo, eye-blink rate increased by 2.1 blinks/min in the iron-deficient anemic group (P = 0.008); there was no change in the nonanemic group (P = 0.96). These results are consistent with reduced dopamine function in iron-deficient anemic infants. The clinical importance of a lower eye-blink rate is unclear, but impaired dopamine functioning is likely to have broader impact, given the role dopamine plays in regulating movement, motivation, cognition, and hormone release.
Authors:
Betsy Lozoff; Rinat Armony-Sivan; Niko Kaciroti; Yuezhou Jing; Mari Golub; Sandra W Jacobson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-24
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-04     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1057-61     Citation Subset:  IM    
Affiliation:
Center for Human Growth and Development and; 4Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA. blozoff@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / drug therapy,  physiopathology*
Blinking / drug effects,  physiology*
Dopamine / physiology*
Humans
Infant
Iron / deficiency,  pharmacology*,  therapeutic use
Michigan
Poisson Distribution
Reference Values
Time Factors
Trace Elements / deficiency,  pharmacology*,  therapeutic use
Grant Support
ID/Acronym/Agency:
P01 HD039386/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Trace Elements; 7439-89-6/Iron
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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