| Extremely preterm infants (< 28 weeks) are capable of gluconeogenesis from glycerol on their first day of life. | |
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MedLine Citation:
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PMID: 8888282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extremely preterm infants have been shown capable of producing glucose at a rate comparable to that of term infants, but virtually no data are available on their capacity for lipolysis and gluconeogenesis. To address this issue, we studied the flux of glycerol and its gluconeogenic contribution to hepatic glucose output by determining the endogenous plasma appearance rate of glycerol (glycerol Ra) and its conversion to glucose in 10 newborn infants, 24-27 wk of gestational age. The study was performed during the 1st d of life by tracer dilution technique using [6,6-2H2]glucose and [2-13C]glycerol given as constant rate i.v. infusions. Plasma isotopic enrichments of the tracers were obtained by gas chromatography/mass spectrometry. Endogenous glycerol Ra ranged from 2.4 to 21.6 (median 5.0) mumol.kg-1.min-1, of which 31.5% (25.6-64.4%) was converted to glucose. The glucose production rate averaged 17.5 +/- 5.4 mumol.kg-1.min-1 (3.2 +/- 1.0 mg.kg-1.min-1), of which 5.0% (1.6-37.6%) was derived from glycerol. The results show that extremely preterm infants, despite limited fat stores, are capable of generating glycerol at a rate within the range reported for term and near term newborns. The infants were also capable of converting part of this glycerol to glucose, providing a contribution to hepatic glucose production comparable to that found in more mature newborns. |
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Authors:
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A Sunehag; U Ewald; J Gustafsson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 40 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1997-02-18 Completed Date: 1997-02-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 553-7 Citation Subset: IM |
Affiliation:
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Uppsala University Children's Hospital, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Carbon Isotopes Deuterium Gas Chromatography-Mass Spectrometry Gestational Age Glucagon / blood Gluconeogenesis* Glucose / metabolism Glycerol / metabolism* Humans Infant, Newborn Infant, Premature / metabolism* Insulin / blood Isotope Labeling / methods Liver / metabolism Radioisotope Dilution Technique Thyrotropin / blood Tritium |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 10028-17-8/Tritium; 11061-68-0/Insulin; 50-99-7/Glucose; 56-81-5/Glycerol; 7782-39-0/Deuterium; 9002-71-5/Thyrotropin; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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