| Extremely low dose of acrylamide decreases lifespan in Caenorhabditis elegans. | |
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MedLine Citation:
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PMID: 15302100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The neurotoxic, genotoxic and carcinogenic effects of industrial exposure to acrylamide have been studied in animals and humans for more than 30 years. A recent search for the cause of high background levels of acrylamide in industrially unexposed people revealed that it is formed during the frying or baking of foods by means of the Maillard reaction. To evaluate the biological consequences of continuous exposure to acrylamide at levels found in common foodstuffs, we studied the effects of acrylamide on the three parameters of (1) growth, (2) fecundity and (3) lifespan in the nematode Caenorhabditis elegans. As for growth and fecundity, no deleterious consequences were observed when the animals were raised in the acrylamide concentrations of 0.5 microg/L to 5mg/L, which are commonly found in daily consumed foodstuffs. Conversely, in 500 mg/L of acrylamide, they showed retarded growth with reduced body and brood sizes. Unlike the first two parameters, however, lifespan decreased significantly even in 0.5 microg/L of acrylamide, the maximum theoretical concentration allowed in drinking water by the WHO and US EPA. Very interestingly, the acrylamide effect on lifespan is biphasic as lifespan increased to near normalcy in 5 mg/L and decreased again in 500 mg/L. |
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Authors:
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Koichi Hasegawa; Satsuki Miwa; Kaname Tsutsumiuchi; Hajime Taniguchi; Johji Miwa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology letters Volume: 152 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-10 Completed Date: 2004-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 183-9 Citation Subset: IM |
Affiliation:
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Institute for Biological Function, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylamide
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toxicity* Animals Caenorhabditis elegans* Dose-Response Relationship, Drug Longevity / drug effects* Reproduction / drug effects Toxicity Tests |
| Chemical | |
Reg. No./Substance:
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79-06-1/Acrylamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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