Document Detail


Extremely Low Frequency Magnetic Fields Do Not Elicit Oxidative Stress in MCF10A Cells.
MedLine Citation:
PMID:  22302048     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The aim of this study was to determine whether extremely low frequency magnetic fields (ELF-MF) could affect intracellular reactive oxygen species (ROS) levels and antioxidant enzyme activity. After MCF10A human breast epithelial cells were exposed to 1 mT of 60 Hz ELF-MF for 4 hours, intracellular ROS level, superoxide dismutase (SOD) activity, and reduced to oxidized glutathione (GSH/GSSG) ratio were measured. The cells exposed to ELF-MF did not evidence statistically significant changes in the above-mentioned biological parameters as compared to either the incubator controls or sham-exposed cells. By way of contrast, the IR-exposed cells exhibited marked changes in ROS level, SOD activity, and GSH/GSSG ratio. When we assessed morphological changes and senescence-associated beta-galactosidase (SA-β-Gal) activity, only the IR-exposed cells were positive. According to our results, it could be concluded that ELF-MF has no effect on intracellular ROS level, SOD activity, and GSH/GSSG ratio under our exposure condition.
Authors:
Mi-Na Hong; Na-Kyung Han; Hyung-Chul Lee; Young-Kyu Ko; Sung-Gil Chi; Yun-Sil Lee; Yoon-Myung Gimm; Sung-Ho Myung; Jae-Seon Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of radiation research     Volume:  53     ISSN:  1349-9157     ISO Abbreviation:  J. Radiat. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376611     Medline TA:  J Radiat Res (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  79-86     Citation Subset:  IM    
Affiliation:
Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences.
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