Document Detail


Extreme mountain bike challenges may induce sub-clinical myocardial damage.
MedLine Citation:
PMID:  16998457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The relationship between extreme exercise and coronary artery disease is not well understood, and the information available is contradictory. The aim of the present study was to determine whether strenuous endurance exercise, performed under conditions in which the partial pressure of environmental oxygen varies constantly, can induce myocardial cell injury. METHODS: Plasma urea, creatinine, creatine kinase, myoglobin and cardiac troponin I (cTnI) concentrations were measured the day before and immediately after a mountain bike challenge (distance 95 km, cumulative altitude difference 2340 m) in eleven amateur male cyclists. RESULTS: All biochemical markers of muscle cell damage increased significantly after exercise. Although cTnI concentrations also increased significantly, they remained below the threshold (0.5 microg/L) indicative of acute myocardial infarction. CONCLUSIONS: In male, amateur mountain bikers, this kind of strenuous exercise may induce sub-clinical myocardial injury.
Authors:
F B Ortega; J R Ruiz; A Gutiérrez; M J Castillo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of sports medicine and physical fitness     Volume:  46     ISSN:  0022-4707     ISO Abbreviation:  J Sports Med Phys Fitness     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2007-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376337     Medline TA:  J Sports Med Phys Fitness     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  489-93     Citation Subset:  IM    
Affiliation:
Research Group EFFECTS 262, Sotogrande Health Experience, Department of Medical Physiology, School of Medicine, University of Granada, Granada, Spain. ortegaf@ugr.es
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MeSH Terms
Descriptor/Qualifier:
Adult
Bicycling / injuries*
Biological Markers / blood
Blood Urea Nitrogen
Coronary Artery Disease / blood,  etiology,  physiopathology
Creatine Kinase / blood
Creatinine / blood
Humans
Male
Middle Aged
Myocardial Infarction / blood,  etiology*,  physiopathology
Myocytes, Cardiac / metabolism,  pathology
Myoglobin / blood
Physical Endurance
Plasma Volume
Troponin I / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Myoglobin; 0/Troponin I; 60-27-5/Creatinine; EC 2.7.3.2/Creatine Kinase

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