Document Detail

Extreme maternal underweight and feto-infant morbidity outcomes: a population-based study.
MedLine Citation:
PMID:  19530001     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to estimate the association between severity of maternal pre-pregnancy underweight and feto-infant morbidity outcomes. METHODS: Missouri maternally linked cohort records from 1989 to 1997 inclusive were analysed. Using pre-pregnancy maternal body mass index (BMI), we classified study participants into: Normal (18.5-24.9) [referent group], mild thinness (17.0-18.5), moderate thinness (16.0-16.9) and severe thinness (<16.0). We estimated the association between pre-pregnancy underweight, underweight subtypes and feto-infant morbidity outcomes using adjusted odds ratios to approximate relative risks with correction for intra-cluster correlations. RESULTS: Fetal growth curve trajectories for the two groups became divergent as from 30 gestational weeks. Underweight mothers were at increased risk for low birthweight (OR = 1.82; 95% CI = 1.77-1.88), very low birthweight (OR = 1.41; 95% CI = 1.31-1.51), small for gestational age (OR = 1.80; 95% CI = 1.76-1.84), preterm (OR = 1.37; 95% CI = 1.33-1.40) and very preterm (OR = 1.42; 95% CI = 1.34-1.50). These risk estimates increased in a dose-effect fashion with increasing severity of underweight status except for very preterm (p for trend < 0.01). CONCLUSION: Pre-pregnancy underweight is a risk factor for a spectrum of feto-infant morbidity outcomes, with risk estimates being most pronounced among extremely underweight mothers.
Hamisu M Salihu; O'Neil Lynch; Amina P Alio; Alfred K Mbah; Jennifer L Kornosky; Phillip J Marty
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  22     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  428-34     Citation Subset:  IM    
The Chiles Centre for Healthy Mothers and Babies, University of South Florida, Tampa, Florida 33613, USA.
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MeSH Terms
Body Mass Index
Cohort Studies
Fetal Diseases / epidemiology*,  etiology
Infant, Newborn
Infant, Newborn, Diseases / epidemiology*,  etiology
Maternal-Fetal Exchange / physiology
Mothers* / statistics & numerical data
Obstetric Labor Complications / epidemiology,  etiology
Pregnancy Complications / epidemiology*
Pregnancy Outcome
Thinness / complications*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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