| Extreme immaturity: outcome of 568 pregnancies of 23-26 weeks' gestation. | |
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MedLine Citation:
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PMID: 8515906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To provide guidelines to the perinatologist regarding extremely premature infants based on the experience of the University of Toronto Newborn Service (two high-risk perinatal units and one outborn neonatal intensive care unit), with a catchment area of 60,000 deliveries annually. METHODS: The study included all births or admissions in the Newborn Service from January 1, 1982 to June 30, 1987 with gestational age determined by the best obstetric estimate of gestational age, ranging from 23-26 completed weeks. The obstetric records were reviewed and the surviving infants followed prospectively for a minimum of 2 years after delivery. RESULTS: Analysis of the neonatal and 2-year follow-up data on 568 infants born between 23-26 weeks' gestation revealed a 39% mortality rate, which increased with decreasing gestation. The highest mortality rates occurred following complicated pregnancies, including fetal growth restriction. Intact survival increased with increasing gestational age, from 11% at 23 weeks to 50% at 26 weeks. There was a marked improvement in both mortality and morbidity by 25 completed weeks. CONCLUSIONS: The results suggest that an aggressive approach before 24 completed weeks' gestation is not warranted. From a total of 60,000 live births per year, only one child born at 23 weeks' gestation and three at 24 weeks were free of major handicap at 2 years. |
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Authors:
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H E Whyte; P M Fitzhardinge; A T Shennan; K Lennox; L Smith; J Lacy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 82 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-07-22 Completed Date: 1993-07-22 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Blindness / congenital Cerebral Palsy / epidemiology Child Development Child, Preschool Cohort Studies Deafness / congenital Female Follow-Up Studies Gestational Age Humans Infant Infant Mortality Infant, Newborn Infant, Premature* Male Neurologic Examination Pregnancy Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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