| Extreme central acidosis from Abbott epinephrine. | |
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MedLine Citation:
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PMID: 6849327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Investigation into the cause of extreme systemic acidosis during cardiac arrest led to the discovery that a major contributing factor was Abbott 1:10,000 single-dose epinephrine, which contained a large unsuspected acid level. Analysis of this product, both in vivo and in vitro, demonstrated that it contained 8.2 times the acid content of a presumably identical product from Bristol Laboratories and also of a presumably identical product from Bristol Laboratories and also 1,850 times the acid content of an identical epinephrine dose made from a Parke-Davis preparation. Abbott epinephrine injected into the central circulation or directly into the heart causes extreme acidemia, which may be potentially lethal by itself when superimposed on pre-existing acidosis as in cardiac arrest. |
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Authors:
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J Feldschuh; R Gambino |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 74 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1983 Jan |
Date Detail:
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Created Date: 1983-02-14 Completed Date: 1983-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 30-2 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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chemically induced* Epinephrine / administration & dosage, adverse effects*, analysis Heart Arrest / blood, drug therapy Humans Hydrogen-Ion Concentration |
| Chemical | |
Reg. No./Substance:
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51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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