| Extravascular pressure modulates responses of isolated rat coronary arteries to vasodilator, but not vasoconstrictor, stimuli. | |
| | |
MedLine Citation:
|
PMID: 16243921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aims of the study were to investigate whether elevated extravascular pressure modulates responses of isolated rat coronary arteries to constrictor and dilator stimuli. Isolated segments of rat coronary artery were mounted in a modified pressure myograph system that allowed independent modulation of both intra- and extravascular pressures. The influence of elevated extravascular pressure on stable levels of myogenic tone and on responses to vasoconstrictor and vasodilator stimuli was investigated at constant overall transmural pressures. Stable levels of myogenic tone were independent of the relative levels of intra- and extravascular pressure, as were responses to depolarization and to addition of the thromboxane agonist U-46619. Elevating extravascular pressure, however, significantly reduced dilatory responses to introduction of intraluminal flow and to addition of endothelium-dependent and endothelium-independent vasodilatory agonists. These results support the notion that elevated extravascular pressure may attenuate responses of coronary arteries to a variety of dilatory stimuli. This finding may be of relevance to cardiac disorders associated with elevated ventricular pressures. |
| | |
Authors:
|
May Azzawi; Clare Austin |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-21 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 290 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-02-09 Completed Date: 2006-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H1151-6 Citation Subset: IM |
Affiliation:
|
Smooth Muscle Physiology Group, Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological
/
drug effects,
physiology Animals Coronary Circulation / drug effects, physiology Coronary Vessels / drug effects, physiology* Male Pressure Rats Rats, Wistar Vascular Resistance / drug effects, physiology Vasoconstriction / drug effects, physiology* Vasoconstrictor Agents / administration & dosage* Vasodilation / drug effects, physiology* Vasodilator Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Vasoconstrictor Agents; 0/Vasodilator Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cardiomyocyte function associated with hyperactivity and/or hypertension in genetic models of LV hyp...
Next Document: Consequences of using different methods to assess cardiovascular risk in primary care.