| Extravascular contrast material: the major component of contrast enhancement. | |
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MedLine Citation:
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PMID: 981616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution volume of 125l-diatrizoate in rat tissues was studied 5 seconds to 5 minutes after intravenous injection and 5 seconds to 2 minutes after intra-arterial injection. Immediately after injection, diatrizoate was distributed into a larger volume than plasma. Marked temporal changes in the distribution volume of individual tissues occurred during the first 2 minutes. At 5 minutes, the diatrizoate space approached the total extracellular fluid volume, with more than 80% of the contrast agent remaining outside the blood vessels. Thus the relative magnitude of contrast enhancement of a tissue appears to be related to the volume of the rapidly equilibrating extracellular space. Intra-arterial administration can significantly overload muscle with contrast material for about 2 minutes. This and other temporal changes in contrast distribution may prove useful in contrast-enhanced computed tomography using short scanning times. |
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Authors:
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M Kormano; P B Dean |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiology Volume: 121 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1976 Nov |
Date Detail:
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Created Date: 1976-12-23 Completed Date: 1976-12-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 379-82 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Animals Contrast Media* Diatrizoate Meglumine / metabolism Extracellular Space / metabolism Male Muscles / metabolism Radiographic Image Enhancement* Rats Testis / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 131-49-7/Diatrizoate Meglumine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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