Document Detail


Extravasation of pegylated-liposomal doxorubicin: favorable outcome after immediate subcutaneous administration of corticosteroids.
MedLine Citation:
PMID:  22515126     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
A massive extravasation of pegylated-liposomal doxorubicin (Doxil) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a corticosteroid preparation was immediately injected subcutaneously into the surrounding tissues. Clobetasol propionate and an ice pack were then topically applied to the affected region. There were no serious complications at the extravasation site, such as tissue necrosis or severe pain, and only a transient erythema of the skin and desquamation remained after 2 months.
Authors:
Ayako Mitsuma; Masataka Sawaki; Takashi Shibata; Sachi Morita; Megumi Inada; Tomoya Shimokata; Mihoko Sugishita; Koichi Kitagawa; Masaki Sawada; Akihiro Nawa; Yuichi Ando
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nagoya journal of medical science     Volume:  74     ISSN:  0027-7622     ISO Abbreviation:  Nagoya J Med Sci     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-04-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0412011     Medline TA:  Nagoya J Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  IM    
Affiliation:
Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan. ayakom@med.nagoya-u.ac.jp
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