Document Detail

Extravasation assay for the assessment of intestinal reactions to orally presented compounds.
MedLine Citation:
PMID:  3715926     Owner:  NLM     Status:  MEDLINE    
Adverse reactions characteristic of food intolerance are claimed to occur in susceptible individuals following exposure to various chemical additives used to colour, flavour or preserve food. The objective of the present study was to develop a method suitable for investigating the nature and mechanism of these reactions in an animal model. Our results demonstrate that intestinal responses, elicited either specifically following oral challenge by antigen or non-specifically by the direct action of a chemical, can be quantified by evaluating the intestinal extravasation (IEV) of intravenously administered 125I-labelled rat albumin.
S Nicklin; A P Hutchinson; K Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  31     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-07-14     Completed Date:  1986-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  167-73     Citation Subset:  IM    
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MeSH Terms
Extravasation of Diagnostic and Therapeutic Materials
Food Additives / immunology,  toxicity*
Food Coloring Agents / immunology,  toxicity
Food Hypersensitivity
Injections, Intraperitoneal
Injections, Intravenous
Intestines / drug effects*,  immunology
Iodine Radioisotopes / diagnostic use
Models, Biological
Ovalbumin / immunology*
Reg. No./Substance:
0/Food Additives; 0/Food Coloring Agents; 0/Iodine Radioisotopes; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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