| Extrauterine growth restriction in preterm infants: importance of optimizing nutrition in neonatal intensive care units. | |
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MedLine Citation:
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PMID: 16158465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extrauterine growth restriction in preterm infants secondary to suboptimal nutrition is a major problem in neonatal intensive care units. Evidence is emerging that early growth deficits have long-term adverse effects, including short stature and poor neurodevelopmental outcomes. The parenteral route of feeding is essential to maintain nutritional integrity before successful transition to the enteral route of feeding is achieved. Nevertheless, early initiation of enteral feeding in sub-nutritional trophic quantity is vital for promoting gut motility and bile secretion, inducing lactase activity, and reducing sepsis and cholestatic jaundice. Results emerging from over sixty randomized clinical trials are available for providing a template on which feeding protocols can be based. Preterm breast milk expressed from the infant's own mother is the milk of choice. Supplementation with a human milk fortifier is necessary to optimize nutritional intake. Preterm formulas are an appropriate substitute for preterm human milk when the latter is unavailable. There are over ten systematic reviews of randomized controlled trials published by the Cochrane Library that addressed feeding strategies, but most do not address long-term outcome measures of clinical importance. There is an urgent need for large-scale, long-term randomized controlled trials to help evaluate metabolic, growth, and neurodevelopmental responses of preterm infants to earlier and more aggressive nutritional management. |
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Authors:
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Victor Y H Yu |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Croatian medical journal Volume: 46 ISSN: 0353-9504 ISO Abbreviation: Croat. Med. J. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-13 Completed Date: 2005-12-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9424324 Medline TA: Croat Med J Country: Croatia |
Other Details:
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Languages: eng Pagination: 737-43 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Ritchie Centre for Baby Health Research, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia. victor.yu@med.monash.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Enteral Nutrition Fetal Growth Retardation* Humans Infant Infant Nutritional Physiological Phenomena* Infant, Newborn Infant, Premature / growth & development* Intensive Care Units* Intensive Care, Neonatal* Parenteral Nutrition |
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