Document Detail

Extrauterine growth restriction in preterm infants: importance of optimizing nutrition in neonatal intensive care units.
MedLine Citation:
PMID:  16158465     Owner:  NLM     Status:  MEDLINE    
Extrauterine growth restriction in preterm infants secondary to suboptimal nutrition is a major problem in neonatal intensive care units. Evidence is emerging that early growth deficits have long-term adverse effects, including short stature and poor neurodevelopmental outcomes. The parenteral route of feeding is essential to maintain nutritional integrity before successful transition to the enteral route of feeding is achieved. Nevertheless, early initiation of enteral feeding in sub-nutritional trophic quantity is vital for promoting gut motility and bile secretion, inducing lactase activity, and reducing sepsis and cholestatic jaundice. Results emerging from over sixty randomized clinical trials are available for providing a template on which feeding protocols can be based. Preterm breast milk expressed from the infant's own mother is the milk of choice. Supplementation with a human milk fortifier is necessary to optimize nutritional intake. Preterm formulas are an appropriate substitute for preterm human milk when the latter is unavailable. There are over ten systematic reviews of randomized controlled trials published by the Cochrane Library that addressed feeding strategies, but most do not address long-term outcome measures of clinical importance. There is an urgent need for large-scale, long-term randomized controlled trials to help evaluate metabolic, growth, and neurodevelopmental responses of preterm infants to earlier and more aggressive nutritional management.
Victor Y H Yu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Croatian medical journal     Volume:  46     ISSN:  0353-9504     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-12-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  737-43     Citation Subset:  IM    
Department of Paediatrics, Ritchie Centre for Baby Health Research, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia.
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MeSH Terms
Enteral Nutrition
Fetal Growth Retardation*
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Infant, Premature / growth & development*
Intensive Care Units*
Intensive Care, Neonatal*
Parenteral Nutrition

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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