| Extratelomeric functions of telomerase. | |
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MedLine Citation:
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PMID: 15974878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomerase reverse transcriptase (TERT), a catalytic subunit of telomerase, has been demonstrated to exert a reverse transcriptase function when combined with telomerase RNA component (TERC), the complex of which ensures the maintenance of telomere length in all eukaryotes. Telomerase also prevents cell death, and promotes survival in many types of cells, from various tissues or organs including neurons, muscle, and immune cells, as well as a variety of tumor cells. Recently, a new aspect of telomerase activity, independent of telomere lengthening, has emerged to explain its protective effects on cell survival. Consistent with this, TERT was found to enhance tumorigenesis, and to regulate the expression of genes that control cell growth, which cannot be explained by telomere stabilization per se. Furthermore, the observation that TERT resides not only in the nucleus, but also in the cytosol, reinforces the notion of possible telomere-independent functions. In this review, recent studies regarding the extratelomeric functions of TERT have been comprehensively summarized, and their implications discussed. |
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Authors:
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Hee Kyoung Chung; Cheolho Cheong; Jaewhan Song; Han-Woong Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current molecular medicine Volume: 5 ISSN: 1566-5240 ISO Abbreviation: Curr. Mol. Med. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-06-24 Completed Date: 2005-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101093076 Medline TA: Curr Mol Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 233-41 Citation Subset: IM |
Affiliation:
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Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon 440-746, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleus / enzymology Cytoplasm / enzymology DNA Repair DNA-Binding Proteins Gene Expression Regulation Humans Mice Muscle Cells / enzymology T-Lymphocytes / enzymology Telomerase / analysis, physiology* Telomere / metabolism |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; EC 2.7.7.49/TERT protein, human; EC 2.7.7.49/Telomerase; EC 2.7.7.49/Tert protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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