| Extrarenal role of aldosterone in the regulation of blood pressure. | |
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MedLine Citation:
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PMID: 3390321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the hypothesis that aldosterone may have direct vasoconstrictive action, the acute effects of canrenoate potassium (Soldactone, S), an aldosterone antagonist, on hemodynamics and hormonal responses were determined before and after the intravenous administration of 2 mg/kg S in 11 patients with primary aldosteronism (PA), 9 patients with essential hypertension (EH), and 5 patients with renovascular hypertension (RVH). S caused a significant -12 +/- 2 mm Hg decrease in MBP in PA, -5 +/- 2 mm Hg in EH, and -4 +/- 1 mm Hg in RVH. Reduction in MBP was significantly higher in PA than in the others and there was a negative correlation between changes in MBP and basal PAC. The cardiac index did not change throughout the study in all groups, which led to a significant reduction in total peripheral resistance index (TPRI) in PA but not in the others. There was a significant correlation between changes in MBP and TPRI (r = 0.82, p less than 0.01). PRA did not change throughout the study, but PAC and cortisol were significantly elevated. There were no correlations between changes in MBP and hormonal responses. In conclusion, S resulted in a significant reduction of MBP mediated by a significant reduction of TPRI. These results suggest that aldosterone may have direct vasoconstrictive action and this extrarenal effect of aldosterone may be involved in the regulation of blood pressure. |
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Authors:
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M Yamakado; M Nagano; M Umezu; H Tagawa; H Kiyose; S Tanaka |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hypertension Volume: 1 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1988-08-22 Completed Date: 1988-08-22 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 276-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aldosterone / blood, physiology* Blood Pressure / drug effects* Canrenoate Potassium / administration & dosage Humans Hydrocortisone / blood Hyperaldosteronism / physiopathology Hypertension, Renovascular / physiopathology Kidney / physiology* Middle Aged Vascular Resistance / drug effects Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
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2181-04-6/Canrenoate Potassium; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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