| Extrapyramidal syndrome related to lithium-carbamazepine combination therapy at therapeutic serum levels. | |
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MedLine Citation:
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PMID: 20375657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurological disturbances due to lithium-carbamazepine combination therapy are infrequent, and only a few cases have been reported so far. We describe a most unusual case of a patient with a history of bipolar disorder who developed ataxic gait, imbalance, and intention tremor after lithium-and-carbamazepine combination treatment with therapeutic serum levels of both drugs; he recovered completely when carbamazepine was discontinued. We also review the literature about this infrequent relationship, discuss on its proposed origin, and underline its importance as a potential adverse effect in elderly patients, yet with therapeutic or even subtherapeutic serum levels. |
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Authors:
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Jose-Alberto Palma; Roberto Fernandez-Torron; Jaime Gallego Perez-Larraya |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical neuropharmacology Volume: 33 ISSN: 1537-162X ISO Abbreviation: Clin Neuropharmacol Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7607910 Medline TA: Clin Neuropharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 102-3 Citation Subset: IM |
Affiliation:
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Department of Neurology and Neurosurgery, University Clinic of Navarra, Pamplona, Spain. jpalmaca@unav.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimanic Agents
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administration & dosage,
adverse effects*,
blood Bipolar Disorder / complications*, drug therapy Carbamazepine / administration & dosage, adverse effects*, blood Drug Therapy, Combination / adverse effects* Dyskinesia, Drug-Induced / complications* Humans Lithium Compounds / administration & dosage, adverse effects*, blood Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antimanic Agents; 0/Lithium Compounds; 298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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