| Extrapyramidal symptoms associated with antidepressants--a review of the literature and an analysis of spontaneous reports. | |
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MedLine Citation:
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PMID: 20680187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Antidepressant-induced extrapyramidal symptoms (EPS) represent an underrecognized but important clinical entity. We reviewed the literature on new antidepressants and conducted an analysis of cases from the FDA Adverse Event Reporting System (AERS), which has not been published before. METHODS: A literature review was conducted using PubMed, Ovid, MEDLINE, PsycINFO, and the Cochrane Database. Search terms used were extrapyramidal, antidepressants, selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), norepinephrine-dopamine reuptake inhibitors (NDRIs), miscellaneous antidepressants, and monoamine oxidase inhibitors (MAOIs). Inclusion criteria for the FDA AERS analysis were cases of EPS reported by physicians, cases where patients were on one antidepressant, and cases reported between July 2005 and March 2008. Reports of patients who were on concurrent psychotropics were excluded. RESULTS: Our literature review revealed 1 report each of EPS for duloxetine, nefazodone, and bupropion, 3 for escitalopram, and 4 for citalopram. For the FDA AERS analysis, 89 cases met our inclusion criteria: duloxetine was implicated in 66% of cases, sertraline in 10%, escitalopram in 7%, and bupropion in 6%. CONCLUSIONS: EPS have been reported with different classes of antidepressants, are not dose related, and can develop with short-term or long-term use. In view of the risk for significant morbidity and decreased quality of life, clinicians must be aware of the potential for any class of antidepressants to cause these adverse effects. |
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Authors:
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Subramoniam Madhusoodanan; Lada Alexeenko; Renata Sanders; Ronald Brenner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists Volume: 22 ISSN: 1547-3325 ISO Abbreviation: Ann Clin Psychiatry Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8911021 Medline TA: Ann Clin Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 148-56 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, St. John's Episcopal Hospital, Far Rockaway, NY 11691, USA. sdanan@ehs.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenergic Uptake Inhibitors / adverse effects, therapeutic use Adult Adverse Drug Reaction Reporting Systems Aged Aged, 80 and over Akathisia, Drug-Induced / diagnosis Antidepressive Agents / adverse effects*, therapeutic use Antidepressive Agents, Tricyclic / adverse effects, therapeutic use Basal Ganglia Diseases / chemically induced*, diagnosis Cross-Sectional Studies Depressive Disorder / drug therapy* Dose-Response Relationship, Drug Drug Administration Schedule Dyskinesia, Drug-Induced / diagnosis Dystonia / chemically induced, diagnosis Female Humans Male Middle Aged Monoamine Oxidase Inhibitors / adverse effects, therapeutic use Serotonin Uptake Inhibitors / adverse effects, therapeutic use United States United States Food and Drug Administration Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Uptake Inhibitors; 0/Antidepressive Agents; 0/Antidepressive Agents, Tricyclic; 0/Monoamine Oxidase Inhibitors; 0/Serotonin Uptake Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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