Document Detail


Extrapotentials and allorhythmias as an expression of experimental parasystole.
MedLine Citation:
PMID:  15064546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to investigate the dynamics of experimental parasystole taking into consideration the peculiarities of recurrent arrhythmias recorded in clinical settings. MATERIAL AND METHODS: The experiments were conducted on isolated right atria of seven chinchilla rabbits. Parasystolic arrhythmias using periodical one-site electrostimulation were provoked in one atrium, where the sinus node was not affected, and in two atria with the spontaneous low value activity of pacemakers. The parasystolic arrhythmias by the dual-site periodical pacing were provoked in four atria, in which the spontaneous activity had disappeared, while the membrane potential of cardiomyocytes remained at the level of 70 to 80 mV. RESULTS: The parasystolic arrhythmias of the shape of single extrapotentials were obtained in atria when the periods of excitation impulses were within the limits of 0.9-1.2 s, and the differences between these periods being relatively small (0.04-0.2 s). The increase of these differences resulted the various allorhythmias. In cases of single extrapotentials, the recurrence periods of arrhythmias reached 5.6-29 s; while in cases of allorhythmias they shortened to 2.4-4.8 s. CONCLUSION: The parasystoles in isolated atria of rabbits can be induced by two competitive excitation sources. They may manifest themselves through single extrapotentials or allorhythmias, whose form depends on the duration of the periods of excitation impulses, the difference between these durations, as well as on effective refractory periods of atrial cardiomyocytes. The determination and evaluation of the recurrence period of these arrhythmias can serve in any given clinical situation as a supplementary criterion.
Authors:
Irena Grigaliūniene; Mindaugas Skucas; Raimundas Lekas; Arvydas Seskevicius
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Medicina (Kaunas, Lithuania)     Volume:  40     ISSN:  1648-9144     ISO Abbreviation:  Medicina (Kaunas)     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-10-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9425208     Medline TA:  Medicina (Kaunas)     Country:  Lithuania    
Other Details:
Languages:  eng     Pagination:  246-52     Citation Subset:  IM    
Affiliation:
Institute of Cardiology, Kaunas University of Medicine, Sukileliu 17, 3007 Kaunas, Lithuania. aritmiki@kmu.lt
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Arrhythmias, Cardiac / diagnosis,  physiopathology*
Cardiac Complexes, Premature / diagnosis,  physiopathology
Cardiac Pacing, Artificial
Cells, Cultured
Diagnosis, Differential
Electric Stimulation
Electrocardiography
Electrocardiography, Ambulatory
Heart / physiopathology
Heart Atria
Humans
Membrane Potentials
Models, Cardiovascular
Myocardium / cytology
Parasystole / diagnosis,  physiopathology*
Rabbits
Recurrence
Sinoatrial Node / physiopathology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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