Document Detail

Extraosseus plasmacytoma of the pharynx with localized light chain deposition. Case report.
MedLine Citation:
PMID:  19967475     Owner:  NLM     Status:  MEDLINE    
Light chain deposition disease (LCDD) is a rare disorder associated with a clonal proliferation of plasma cells, which synthesize abnormal monoclonal immunoglobulin light chains. It is characterized by systemic deposition of light chains in various organs, with the kidneys being most commonly affected. There have been few reports of isolated LCDD, i.e. in the brain, lungs and cervical lymph nodes. We here report on another patient with an isolated form of LCDD, which was limited to the pharyngeal mucosa and was associated with an extraosseus plasmacytoma of the pharynx, expanding the spectrum that has been recognized for LCDD. The patient was treated by local radiotherapy, with an excellent response. A less aggressive clinical course can probably be expected than in the usual form of LCDD, but a long-term follow-up is necessary to establish the clinical significance of this variant of LCDD.
Nina Zidar; Samo Zver; Vesna Jurcić
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-12-05
Journal Detail:
Title:  Pathology oncology research : POR     Volume:  16     ISSN:  1532-2807     ISO Abbreviation:  Pathol. Oncol. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706087     Medline TA:  Pathol Oncol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  249-52     Citation Subset:  IM    
Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.
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MeSH Terms
Immunoglobulin Light Chains*
Microscopy, Electron, Transmission
Middle Aged
Paraproteinemias / complications,  pathology*,  radiotherapy
Pharyngeal Neoplasms / complications,  pathology*,  radiotherapy
Plasmacytoma / complications,  pathology*,  radiotherapy
Reg. No./Substance:
0/Immunoglobulin Light Chains

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