| Extraosseous langerhans cell histiocytosis in children. | |
| | |
MedLine Citation:
|
PMID: 18480480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Langerhans cell histiocytosis, a rare disease that occurs mainly in children, may produce a broad range of manifestations, from a single osseous lesion to multiple lesions involving more than one organ or system. The clinical course varies widely in relation to the patient's age. Multisystem disease may demonstrate especially aggressive behavior in very young children, with the outcome depending largely on the stage of disease and the degree of related organ dysfunction at the time of diagnosis. Extraosseous manifestations are less commonly seen than osseous ones and may be more difficult to identify. To accurately detect extraosseous Langerhans cell histiocytosis at an early stage, radiologists must recognize the significance of individual clinical and laboratory findings as well as the relevance of imaging features for the differential diagnosis. The pattern and severity of pulmonary, thymic, hepatobiliary, splenic, gastrointestinal, neurologic, mucocutaneous, soft-tissue (head and neck), and salivary involvement in Langerhans cell histiocytosis generally are well depicted with conventional radiography, ultrasonography, computed tomography, and magnetic resonance imaging. However, the imaging features are not pathognomonic, and a biopsy usually is necessary to establish a definitive diagnosis. |
| | |
Authors:
|
Sabine Schmidt; Georg Eich; Anne Geoffray; Sylviane Hanquinet; Peter Waibel; Rainer Wolf; Igor Letovanec; Leonore Alamo-Maestre; Francois Gudinchet |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Radiographics : a review publication of the Radiological Society of North America, Inc Volume: 28 ISSN: 1527-1323 ISO Abbreviation: Radiographics Publication Date: 2008 May-Jun |
Date Detail:
|
Created Date: 2008-05-15 Completed Date: 2008-06-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8302501 Medline TA: Radiographics Country: United States |
Other Details:
|
Languages: eng Pagination: 707-26; quiz 910-1 Citation Subset: IM |
Copyright Information:
|
Copyright RSNA, 2008. |
Affiliation:
|
Department of Diagnostic and Interventional Radiology, Centre Hospitalier Universitaire Vaudois-CHUV, Rue du Bugnon, 1011 Lausanne, Switzerland. sabine.schmidt@chuv.ch |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Child, Preschool Diagnostic Imaging / methods* Female Histiocytosis, Langerhans-Cell / diagnosis* Humans Image Enhancement / methods* Male Multiple Organ Failure / diagnosis* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Normal Doppler spectral waveforms of major pediatric vessels: specific patterns.
Next Document: Bowel wall thickening in children: CT findings.