Document Detail


Extranodal malignant lymphoma: detection with FDG PET versus CT.
MedLine Citation:
PMID:  9457202     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate use of functional imaging with positron emission tomography (PET) versus computed tomography (CT) for detection of extranodal lymphoma spread. MATERIALS AND METHODS: Eighty-one consecutive and previously untreated patients with malignant non-Hodgkin lymphoma (n = 43) or Hodgkin disease (n = 38) were examined with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) PET and contrast material-enhanced CT. Concordant findings at both CT and FDG PET were regarded as actual locations of disease; discordant results were resolved on the basis of biopsy or follow-up results when possible. RESULTS: Forty-two lesions were identified at both PET and CT, and 19 were verified with biopsy results. PET demonstrated a further 24 lesions. Verification was possible in 15 of these lesions with biopsy (n = 10), magnetic resonance imaging (n = 1), scintigraphic (n = 1), or follow-up (n = 3) results. In 14 of these 15 lesions, PET findings were confirmed (bone marrow, nine; spleen, three; other, two). Seven lesions not visualized at FDG PET were identified at CT, six of which were verified with biopsy (n = 2) or follow-up (n = 4) results. Five of these six CT findings were found to be erroneous. In 13 patients, PET findings led to changes in tumor staging. CONCLUSION: PET may provide more information about extranodal lymphoma than does incremental CT.
Authors:
F Moog; M Bangerter; C G Diederichs; A Guhlmann; E Merkle; N Frickhofen; S N Reske
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Radiology     Volume:  206     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-02-26     Completed Date:  1998-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  475-81     Citation Subset:  AIM; IM    
Affiliation:
Department of Nuclear Medicine, University of Ulm, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
False Negative Reactions
False Positive Reactions
Female
Fluorine Radioisotopes / diagnostic use*
Fluorodeoxyglucose F18 / diagnostic use*
Hodgkin Disease / radiography*,  radionuclide imaging*
Humans
Lymphoma, Non-Hodgkin / radiography*,  radionuclide imaging*
Male
Radiopharmaceuticals / diagnostic use*
Tomography, Emission-Computed*
Tomography, X-Ray Computed*
Chemical
Reg. No./Substance:
0/Fluorine Radioisotopes; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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