Document Detail

Extranodal follicular dendritic cell sarcoma of the pharyngeal region: a potential diagnostic pitfall, with literature review.
MedLine Citation:
PMID:  20023258     Owner:  NLM     Status:  MEDLINE    
Extranodal follicular dendritic cell sarcoma (FDCS) of the pharyngeal region is a rare malignant tumor recognized in recent years, with approximately 37 cases so far reported in the literature. It is often not considered at the initial evaluation and may be misdiagnosed in a small biopsy specimen. We report 4 cases of extranodal FDCS, 2 cases in the nasopharynx that were diagnosed as undifferentiated carcinomas because they were characterized by syncytial epithelial cells with sheet or nest-like distribution and 2 cases in the tonsil and soft palate that were characterized by vaguely concentric whorls consisting of spindle to ovoid cells. The latter case was diagnosed as ectopic meningioma. The analysis of all cases from the literature and ours shows that 58% (21/36) of the cases are misdiagnosed initially, often as undifferentiated carcinoma or meningioma, which the differential diagnoses should be mostly focused on. With a median follow-up of 27 months, the recurrence, metastasis, and mortality rates are 23%, 21%, and 3%, respectively, suggesting that extranodal FDCS of the pharyngeal region remains a low-grade sarcoma. Radical surgery is recommended, whereas there is no evidence to support adjuvant therapy.
Guang-jie Duan; Feng Wu; Jiang Zhu; De-yu Guo; Rong Zhang; Li-li Shen; Sheng-hong Wang; Qi Li; Hua-liang Xiao; Jiang-hong Mou; Xiao-chu Yan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  133     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-21     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-58     Citation Subset:  AIM; IM    
Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing, Peoples Republic of China.
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MeSH Terms
Carcinoma / diagnosis*
DNA, Neoplasm / analysis
Dendritic Cell Sarcoma, Follicular / diagnosis*,  surgery
Dendritic Cells, Follicular / ultrastructure*
Diagnostic Errors*
Disease-Free Survival
Giant Cells / pathology
In Situ Hybridization
Middle Aged
Nasopharyngeal Neoplasms / diagnosis*,  surgery
Tomography, X-Ray Computed
Treatment Outcome
Tumor Markers, Biological
Reg. No./Substance:
0/DNA, Neoplasm; 0/Tumor Markers, Biological

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