| Extraneous round window membranes and plugs: possible effect on intratympanic therapy. | |
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MedLine Citation:
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PMID: 10651408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently there has been increasing interest in the possibility of treating inner ear disorders by application of medication into the middle ear on the premise that it will diffuse through the round window membrane into the inner ear. We examined 202 temporal bones from 117 patients to determine the frequency of round window niche obstruction. Patients ranged in age at the time of death from 31 to 97 years. Eleven percent of the ears were found to have fibrous tissue or a fat plug, and 21% had an extraneous (false) round window membrane. Of the 85 patients from whom both temporal bones were examined, 56% had no obstruction in either ear, while 22% had obstruction in both ears. We conclude that anatomic variations of the round window niche may explain the wide variations found in dosage of medication required to produce a clinical result. |
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Authors:
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K S Alzamil; F H Linthicum |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of otology, rhinology, and laryngology Volume: 109 ISSN: 0003-4894 ISO Abbreviation: Ann. Otol. Rhinol. Laryngol. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-02-16 Completed Date: 2000-02-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0407300 Medline TA: Ann Otol Rhinol Laryngol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 30-2 Citation Subset: AIM; IM |
Affiliation:
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Histology Laboratory, House Ear Institute, Los Angeles, California 90057, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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pathology Adult Aged Aged, 80 and over Dose-Response Relationship, Drug Ear Diseases / drug therapy Ear, Inner / pathology Female Fibrosis / pathology Humans Instillation, Drug Male Middle Aged Pharmacokinetics Round Window, Ear / metabolism, pathology* Temporal Bone / pathology Tympanic Membrane / metabolism, pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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