| Extramedullary manifestation of multiple myeloma (systemic plasmacytoma) that simulates hemangioma. | |
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MedLine Citation:
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PMID: 10747326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe 2 cases of a unique type of extramedullary manifestation of multiple myeloma (systemic plasmacytoma) that presented as subcutaneous nodules and mediastinal mass, respectively. Both lesions had a similar morphologic appearance, with dilated vascular-like lumina that was separated by thin fibrovascular septa, filled with erythrocytes, and lined by mature and immature plasma cells and plasmacytoid cells. The plasma and plasmacytoid lining cells showed kappa light chain restriction in both cases, consistent with a B-cell monoclonal process. The lining cells were also focally positive for epithelial membrane antigen but were negative for endothelial cell markers. Abundant delicate capillaries were seen in the septa that separated the vascular lumina, mimicking a vascular tumor. Furthermore, we believe that our cases are different from the previously described blood lakes in a plasmacytoma by the presence of well-formed fibrovascular septa that separated the vascular-like spaces. Neoangiogenesis propagated by myeloma cells may contribute to this unusual morphologic manifestation of extramedullary manifestation of multiple myeloma. |
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Authors:
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M A Nandedkar; S L Abbondanzo; M Miettinen |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 124 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-05-31 Completed Date: 2000-05-31 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 628-31 Citation Subset: AIM; IM |
Affiliation:
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Departments of Hematopathology and Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Diagnosis, Differential Fatal Outcome Female Hemangioma / pathology* Humans Immunoglobulin Light Chains / analysis Immunoglobulin kappa-Chains / analysis Immunohistochemistry Male Mediastinal Neoplasms / immunology, pathology Middle Aged Multiple Myeloma / immunology, pathology* Plasma Cells / pathology Plasmacytoma / immunology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin Light Chains; 0/Immunoglobulin kappa-Chains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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