Document Detail

Extramedullary involvement in acute lymphoblastic leukemia and its relation to therapy.
MedLine Citation:
PMID:  1800337     Owner:  NLM     Status:  MEDLINE    
Extramedullary involvement (EMI) of various body sites was studied by doing CSF cytology anu FNAC of testes and lymph nodes in 82 children with acute lymphoblastic leukemia (ALL). Forty-five patients had received no therapy (group I) and 37 had been diagnosed and treated earlier and were now in remission (36) or relapse (group II). EMI was documented in 48.9% and 32.4% of patients of group I and II respectively. EMI was seen more frequently in patients with FAB-L 2 subtype (66.6%) as compared to FAB-L1 subtype (34.6%) in group I. Lymph nodes and testes were commonly involved in group I and II patients respectively. Successful remission after complete chemotherapy was achieved in 82.5% of group I patients. However, successful remission rates were 95.2% in patients without any evidence of EMI versus 68.4% in those with EMI. These differences were also observed when response to therapy was analysed separately for patients with FAB-L1 and FAB-L2 subtypes.
A V Rao; K Verma; K Kapila; V P Choudhry; H P Pati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  58     ISSN:  0019-5456     ISO Abbreviation:  Indian J Pediatr     Publication Date:    1991 Jul-Aug
Date Detail:
Created Date:  1992-04-23     Completed Date:  1992-04-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  535-41     Citation Subset:  IM    
Department of Pathology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Central Nervous System Neoplasms / therapy*
Child, Preschool
Medulla Oblongata / pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
Testis / pathology

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