| Extramedullary hematopoiesis in hereditary spherocytosis deficient in ankyrin: a case report. | |
| | |
MedLine Citation:
|
PMID: 12215014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hereditary spherocytosis (HS) is a common inherited hemolytic anemia due to red cell membrane defects. Extramedullary hematopoiesis is a compensatory response to insufficient bone marrow blood cell production. The preferred sites of extramedullary hematopoietic involvement are the spleen, liver, and lymph nodes, but in HS the posterior paravertebral mediastinum is also commonly involved. A nonsplenectomized 74-year-old man with mild HS, with primary deficiency in ankyrin, was found by magnetic resonance imaging to have thoracic paravertebral hematopoietic masses. The patient showed high serum levels of erythropoietin, which may have played a role in the development of extramedullary hematopoietic masses through a continuous hematopoietic stimulus to erythroid cells in the propositus. The long-standing history of respiratory infections and of hypoxia in the propositus may have been an additional etiological factor. |
| | |
Authors:
|
E Granjo; R Bauerle; R Sampaio; P Manata; N Torres; A Quintanilha |
Related Documents
:
|
8597064 - Role of cell proliferation at early stages of hepatocarcinogenesis. 12175984 - Pancreatitis-associated ascitic fluid induces hepatocyte death independent of local cyt... 16963314 - Cytokeratin-7, cytokeratin-19, and c-kit: immunoreaction during the evolution stages of... 22433434 - Fibronectin matrix-mediated cohesion suppresses invasion of prostate cancer cells. 12767034 - Endogenous neurotrophic factors enhance neurite growth by bag cell neurons of aplysia. 6182254 - Interferon interactions with thyroid cells. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: International journal of hematology Volume: 76 ISSN: 0925-5710 ISO Abbreviation: Int. J. Hematol. Publication Date: 2002 Aug |
Date Detail:
|
Created Date: 2002-09-06 Completed Date: 2003-07-31 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 153-6 Citation Subset: IM |
Affiliation:
|
Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal. elisagranjo@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Ankyrins* / deficiency Erythropoietin / blood Hematopoiesis, Extramedullary* Humans Magnetic Resonance Imaging Male Respiratory Tract Infections Spherocytosis, Hereditary / blood, complications* Thorax |
| Chemical | |
Reg. No./Substance:
|
0/Ankyrins; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Malays in Malaysia.
Next Document: Severe immune dysfunction after lethal neutron irradiation in a JCO nuclear facility accident victim...