Document Detail

Extramedullary hematopoiesis in the endometrium.
MedLine Citation:
PMID:  11917228     Owner:  NLM     Status:  MEDLINE    
Extramedullary hematopoiesis (EMH) in the endometrium is an extremely rare occurrence. Four of the eight previously reported cases were related to an underlying hematological disorder, although the remainder had no such relationship. We describe a case of endometrial EMH associated with retained products of conception after termination of pregnancy. Routinely and immunohistochemically stained slides revealed several collections of normoblasts and granulocytic precursors in the endometrium with synchronous chronic endometritis. Retained chorionic villi were also identified. The patient had no known history of a hematological disorder or systemic disease and no such abnormality was detected after detailed hematological work-up. Local effects of growth factors on circulating stem cells may play a pathogenetic role in this process, although an association with recent pregnancy in this case suggests that implantation of fetal hematopoietic elements from the fetus or yolk sac may be more likely.
Rosalia M Valeri; Nada Ibrahim; Michael T Sheaff
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  21     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-27     Completed Date:  2004-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  IM    
Department of Histopathology, Barts and the London NHS Trust, Royal London Hospital, Whitechapel, London E1 1BB.
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MeSH Terms
Abortion, Induced*
Endometritis / etiology,  pathology,  surgery
Endometrium / pathology*,  surgery
Hematopoiesis, Extramedullary*
Placenta, Retained / complications,  pathology*,  surgery
Uterine Hemorrhage / etiology,  surgery

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