Document Detail

Extramedullary erythropoiesis in chronic subdural hematoma simulating metastatic small round cell tumor.
MedLine Citation:
PMID:  17652539     Owner:  NLM     Status:  MEDLINE    
We report two cases of extramedullary erythropoiesis within chronic subdural hematoma that caused diagnostic confusion. In both cases, the initial favored diagnosis by the submitting pathologists was that of a metastatic malignant tumor, including lymphoma, carcinoma, and malignant melanoma. In both cases, the subdural chronic hematoma contained cohesive clusters of small round blue cells with scant cytoplasm and round hyperchromatic nuclei. In both cases, some mitotic figures were identified. There was no gross or microscopic evidence of a meningeal mass lesion. The erythroblastic nature of the cells was confirmed using immunohistochemistry for CD43, glycophorin A, and erythropoietin A. It is important for surgical pathologists to be aware of this benign process and not to overinterpret it as either a primary or metastatic malignant tumor.
Elisabetta Kuhn; Tshering Dorji; Jaime Rodriguez; Juan Rosai
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of surgical pathology     Volume:  15     ISSN:  1066-8969     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  288-91     Citation Subset:  IM    
Centro Consulenze Anatomia Patologica Oncologica, Department of Pathology, Centro Diagnostico Italiano, Milan, Italy.
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MeSH Terms
Antigens, CD34 / genetics,  metabolism
Brain Neoplasms / diagnosis,  metabolism,  pathology*
Carcinoma, Small Cell / diagnosis,  metabolism,  pathology*
Diagnosis, Differential
Erythropoietin / genetics,  metabolism
Gene Expression Regulation, Neoplastic
Glycophorin / genetics,  metabolism
Hematoma, Subdural, Chronic / diagnosis,  metabolism,  pathology*
Hematopoiesis, Extramedullary*
Middle Aged
Reg. No./Substance:
0/Antigens, CD34; 0/Glycophorin; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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