Document Detail

Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report.
MedLine Citation:
PMID:  19615013     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Extramammary Paget's disease (EMPD) is an uncommon skin neoplasm characterized by Paget's cells with pale-staining cytoplasm in the epidermis, and cases with distinguished acantholysis but lacking characteristic Paget's cells were rarely reported in the literature. METHODS: An 80-year-old male with lesion on scrotum was screened histologically and immunohistologically for the diagnosis of his tumor. RESULTS: Histological examination showed acanthosis with cellular atypia and focal acantholysis, consistent with acantholytic squamous cell carcinoma in situ (SCCIS). No characteristic Paget's cells were observed in low magnification. Immunohistochemical staining showed carcinoembryonic antigen (CEA), cytokeratin 7 (CK7) and cytokeratin 8 (CK8) to be strongly expressed in the nests and singly arranged large tumor cells, and the surrounding epidermis was positive for CK5/6 and negative for CEA. Sporadic periodic acid-schiff (PAS)-positive cells could be seen in some areas. CONCLUSIONS: These findings strongly indicated the diagnosis of EMPD mimicking acantholytic SCCIS.
Xufeng Du; Xingping Yin; Nan Zhou; Guolong Zhang; Hejian Shi; Shuanglin Cao
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-07-14
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  37     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  683-6     Citation Subset:  IM    
Department of Dermatology, Wuxi People's Hospital, Wuxi 214023, China.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / pathology*
Diagnosis, Differential
Genital Neoplasms, Male / pathology*
Paget Disease Extramammary / pathology*
Scrotum / pathology*

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