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Extramammary Paget disease: Immunohistochemistry is critical to distinguish potential mimickers.
MedLine Citation:
PMID:  23031371     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Extra-mammary Paget disease (EMPD) is a rare intra-epithelial carcinoma that is usually found on the apocrine-rich skin of the perineum. We report 2 cases in which EMPD was initially misdiagnosed on the initial punch biopsy as melanoma-in-situ and Bowen disease respectively. Reasons for the misdiagnoses included a rare pigmented axillary variant of EMPD in the first case and atypical bowenoid features on H&E in the second. The cases are described with a critical review of the histopathological findings, along with a review of the current literature. This highlights the necessity of a comprehensive immunohistochemical panel for the assessment of intra-epithelial pagetoid atypical cells.
Authors:
Etienne Ce Wang; Yung Chien Kwah; Wee Ping Tan; Joyce Ss Lee; Suat Hoon Tan
Publication Detail:
Type:  Journal Article     Date:  2012-09-15
Journal Detail:
Title:  Dermatology online journal     Volume:  18     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4     Citation Subset:  IM    
Affiliation:
National Skin Centre, Singapore.
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