Document Detail

Extrahepatic synthesis of C6 in the rat is sufficient for complement-mediated hyperacute rejection of a guinea pig cardiac xenograft.
MedLine Citation:
PMID:  7709449     Owner:  NLM     Status:  MEDLINE    
The liver is the major source of complement (C) components, but extrahepatic sources of C, such as macrophages and endothelial cells, have been hypothesized to contribute to inflammation. Our experiments demonstrate that extrahepatically produced C6 can contribute to hyperacute rejection. PVG (RT1c) rats with normal C activity (PVG (C+)) reject guinea pig cardiac xenografts in 0.5 +/- 0.2 hr, but fully C6-deficient PVG (RT1c) rats (PVG (C-)) reject guinea pig cardiac xenografts in 45 +/- 9 hr. PVG (C+) rats, which received liver transplants from PVG (C-) rats and retained all extrahepatic sources of C6, rejected guinea pig cardiac xenografts in 0.6 +/- 0.03 hr (n = 3). PVG (C-) rats, which received bone marrow transplants from PVG (C+) rats, had C6 levels restored to 10% of that of the donor and rejected guinea pig cardiac xenografts in 9 +/- 3.2 hr (n = 5). Thus, extrahepatic sources of C6 can contribute to xenograft rejection.
R B Brauer; T T Lam; D Wang; L R Horwitz; A D Hess; A S Klein; F Sanfilippo; W M Baldwin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation     Volume:  59     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-11     Completed Date:  1995-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1073-6     Citation Subset:  IM    
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
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MeSH Terms
Complement C6 / biosynthesis*,  deficiency
Complement System Proteins / pharmacology*
Endothelium / cytology,  metabolism
Graft Rejection / physiopathology
Guinea Pigs
Heart Transplantation / immunology*
Macrophages / metabolism
Rats, Inbred Strains
Transplantation, Heterologous / immunology*
Transplantation, Heterotopic*
Reg. No./Substance:
0/Complement C6; 9007-36-7/Complement System Proteins

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