| Extrahepatic synthesis of C6 in the rat is sufficient for complement-mediated hyperacute rejection of a guinea pig cardiac xenograft. | |
MedLine Citation:
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PMID: 7709449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The liver is the major source of complement (C) components, but extrahepatic sources of C, such as macrophages and endothelial cells, have been hypothesized to contribute to inflammation. Our experiments demonstrate that extrahepatically produced C6 can contribute to hyperacute rejection. PVG (RT1c) rats with normal C activity (PVG (C+)) reject guinea pig cardiac xenografts in 0.5 +/- 0.2 hr, but fully C6-deficient PVG (RT1c) rats (PVG (C-)) reject guinea pig cardiac xenografts in 45 +/- 9 hr. PVG (C+) rats, which received liver transplants from PVG (C-) rats and retained all extrahepatic sources of C6, rejected guinea pig cardiac xenografts in 0.6 +/- 0.03 hr (n = 3). PVG (C-) rats, which received bone marrow transplants from PVG (C+) rats, had C6 levels restored to 10% of that of the donor and rejected guinea pig cardiac xenografts in 9 +/- 3.2 hr (n = 5). Thus, extrahepatic sources of C6 can contribute to xenograft rejection. |
Authors:
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R B Brauer; T T Lam; D Wang; L R Horwitz; A D Hess; A S Klein; F Sanfilippo; W M Baldwin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplantation Volume: 59 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-05-11 Completed Date: 1995-05-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1073-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Complement C6 / biosynthesis*, deficiency Complement System Proteins / pharmacology* Endothelium / cytology, metabolism Graft Rejection / physiopathology Guinea Pigs Heart Transplantation / immunology* Liver Macrophages / metabolism Male Rats Rats, Inbred Strains Transplantation, Heterologous / immunology* Transplantation, Heterotopic* |
| Chemical | |
Reg. No./Substance:
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0/Complement C6; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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