Document Detail

Extrahepatic manifestations of viral hepatitis.
MedLine Citation:
PMID:  242219     Owner:  NLM     Status:  MEDLINE    
Recent evidence indicates that viral hepatitis is sometimes associated with the production of extrahepatic tissue injury. Hepatitis B virus (HBV) infection is most commonly incriminated but non-type B hepatitis may also be involved. Three types of syndromes have been recognized. First, a serum sickness-like prodrome consisting of skin eruptions, urticaria and polyarthralgias or arthritis may occur from one to six weeks prior to the onset of hepatitis in 15 to 20 per cent of patients and usually disappears by the time the patient becomes jaundiced. There is extensive evidence that circulating immune complexes are responsible for these symptoms. Second, about 30 to 40 per cent of patients with typical polyarteritis nodosa have persistent hepatitis B surface antigenemia (HBs Ag). Circulating immune complexes composed of HBs Ag, antibody, and complement have been demonstrated together with deposits of immune complexes at sites of vascular injury. Third, an immune complex type of glomerulonephritis may occur following hepatitis B virus infection, usually in association with chronic active hepatitis. Thus there is impressive evidence that hepatitis viruses, especially HBV, may produce a variety of extrahepatic manifestations in which the mechanism of pathogenesis involves an immunologic process rather than direct viral invasion and cytopathogenicity.
D J Gocke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  270     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:    1975 Jul-Aug
Date Detail:
Created Date:  1976-01-08     Completed Date:  1976-01-08     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  AIM; IM    
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MeSH Terms
Complement System Proteins / analysis
Glomerulonephritis / immunology
Hepatitis A / complications*,  immunology
Hepatitis B / complications*,  immunology
Hepatitis B Antigens / analysis
Hepatitis B virus / isolation & purification
Hepatovirus / isolation & purification
Immune Complex Diseases / etiology*
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Polyarteritis Nodosa / etiology,  immunology
Reg. No./Substance:
0/Hepatitis B Antigens; 0/Immunoglobulin G; 0/Immunoglobulin M; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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