| Extragenital adenosarcoma: a case report, review of the literature, and management discussion. | |
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MedLine Citation:
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PMID: 19712965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Müllerian adenosarcoma is a rare mixed epithelial-mesenchymal tumor. An extragenital site of origin and sarcomatous overgrowth are associated with aggressive clinical behavior. CASE: We present a rare case of extragenital adenosarcoma with sarcomatous overgrowth and coexistent endometriosis. She was treated with initial cytoreductive surgery and chemotherapy. She underwent a second surgery for management of a high-grade bowel obstruction, due to pathologically confirmed recurrent intraperitoneal adenosarcoma. A complete clinical response was achieved with liposomal doxorubicin, and the patient remains disease-free eighteen months after completion of chemotherapy. CONCLUSION: Liposomal doxorubicin appears to be an active agent for the treatment of adenosarcoma with sarcomatous overgrowth. In addition, we conclude from our review of all reported cases of extragenital adenosarcoma that concurrent endometriosis may represent a favorable prognostic factor. |
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Authors:
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Gloria S Huang; Rebecca C Arend; Antoinette Sakaris; Tiffany M Hebert; Gary L Goldberg |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural Date: 2009-08-26 |
Journal Detail:
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Title: Gynecologic oncology Volume: 115 ISSN: 1095-6859 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-03 Completed Date: 2009-12-01 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 472-5 Citation Subset: IM |
Affiliation:
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Division of Gynecologic Oncology, Department of Obstetrics & Gynecology and Women's Health, Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, Albert Einstein Cancer Center, 1695 Eastchester Road, Suite 601, Bronx, NY 10461, USA. ghuang@montefiore.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosarcoma
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drug therapy*,
pathology,
surgery* Adult Endometriosis / pathology Female Genital Neoplasms, Female / drug therapy*, pathology, surgery* Humans |
| Grant Support | |
ID/Acronym/Agency:
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5K12HD00849/HD/NICHD NIH HHS; L30 CA124342-02/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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