Document Detail


Extragenital adenosarcoma: a case report, review of the literature, and management discussion.
MedLine Citation:
PMID:  19712965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Müllerian adenosarcoma is a rare mixed epithelial-mesenchymal tumor. An extragenital site of origin and sarcomatous overgrowth are associated with aggressive clinical behavior.
CASE: We present a rare case of extragenital adenosarcoma with sarcomatous overgrowth and coexistent endometriosis. She was treated with initial cytoreductive surgery and chemotherapy. She underwent a second surgery for management of a high-grade bowel obstruction, due to pathologically confirmed recurrent intraperitoneal adenosarcoma. A complete clinical response was achieved with liposomal doxorubicin, and the patient remains disease-free eighteen months after completion of chemotherapy.
CONCLUSION: Liposomal doxorubicin appears to be an active agent for the treatment of adenosarcoma with sarcomatous overgrowth. In addition, we conclude from our review of all reported cases of extragenital adenosarcoma that concurrent endometriosis may represent a favorable prognostic factor.
Authors:
Gloria S Huang; Rebecca C Arend; Antoinette Sakaris; Tiffany M Hebert; Gary L Goldberg
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2009-08-26
Journal Detail:
Title:  Gynecologic oncology     Volume:  115     ISSN:  1095-6859     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-03     Completed Date:  2009-12-01     Revised Date:  2011-05-05    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-5     Citation Subset:  IM    
Affiliation:
Division of Gynecologic Oncology, Department of Obstetrics & Gynecology and Women's Health, Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, Albert Einstein Cancer Center, 1695 Eastchester Road, Suite 601, Bronx, NY 10461, USA. ghuang@montefiore.org
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MeSH Terms
Descriptor/Qualifier:
Adenosarcoma / drug therapy*,  pathology,  surgery*
Adult
Endometriosis / pathology
Female
Genital Neoplasms, Female / drug therapy*,  pathology,  surgery*
Humans
Grant Support
ID/Acronym/Agency:
5K12HD00849/HD/NICHD NIH HHS; L30 CA124342-02/CA/NCI NIH HHS

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