Document Detail

Extradural analgesia in labour. A comparison of 2-chloroprocaine hydrochloride and bupivacaine hydrochloride.
MedLine Citation:
PMID:  532919     Owner:  NLM     Status:  MEDLINE    
Chloroprocaine hydrochloride 2% and bupivacaine hydrochloride 0.375% in 10-ml doses of plain solutions were studied in a randomised blind manner as the agents for continuous lumbar extradural analgesia in labour. Twenty-four patients were assessed for the speed of onset, duration of action, degree of motor blockade, dermatomal spread, arterial hypotension, and the incidence of unblocked segments. Chloroprocaine showed a quicker onset time and a shorter duration of action than bupivacaine. Chloroprocaine exhibited more marked motor blockade and a lower incidence of unblocked segments. The dermatomal spread and effect on arterial pressure were similar in both groups.
P R Allen; R W Johnson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  34     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-04-17     Completed Date:  1980-04-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  839-43     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Epidural*
Anesthesia, Obstetrical*
Bupivacaine* / pharmacology
Evaluation Studies as Topic
Labor, Obstetric
Procaine / analogs & derivatives*,  pharmacology
Random Allocation
Reg. No./Substance:
2180-92-9/Bupivacaine; 59-46-1/Procaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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