Document Detail


Extradural administration of morphine and bupivacaine. A controlled comparison.
MedLine Citation:
PMID:  6362693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Analgesia, following operation, was provided by the extradural administration of morphine or bupivacaine in 24 patients, in a double-blind, randomized, cross-over study. Observations were made of vital signs, peak expiratory flow rate (PEFR), quality and duration of pain relief and the occurrence of adverse effects. Vital signs were little affected by morphine, but hypotension requiring active treatment occurred in three patients following the administration of bupivacaine. The PEFR was improved about equally by each drug, and the improvement was significant compared with control values (P less than 0.001). Pain relief as judged by the linear analogue scale was significantly better following bupivacaine than after morphine (P less than 0.001), but the pain score system, while showing effective pain relief in most patients with both drugs, did not demonstrate a significant difference between them. The duration of effect of morphine was significantly longer (P less than 0.05) than that of bupivacaine. Adverse effects, other than bupivacaine-induced hypotension, were not serious.
Authors:
T A Torda; D A Pybus
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  56     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-03-23     Completed Date:  1984-03-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Bupivacaine / administration & dosage,  therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Epidural Space
Female
Hemodynamics / drug effects
Humans
Injections
Male
Middle Aged
Morphine / administration & dosage,  therapeutic use*
Pain, Postoperative / drug therapy*
Random Allocation
Respiration / drug effects
Time Factors
Chemical
Reg. No./Substance:
2180-92-9/Bupivacaine; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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