Document Detail

Extracts of rhinoceros horn are not antipyretic in rabbits.
MedLine Citation:
PMID:  9363565     Owner:  NLM     Status:  MEDLINE    
We administered extracts of the horn of the African Black rhinoceros intragastrically to 7 rabbits, at the same time as injecting bacterial lipopolysaccharide (LPS) intravenously into the rabbits to produce fever. At a dose of horn (50 mg/kg) similar to that allegedly used to reduce human fever, and at ten times that dose, the fever response to LPS was not significantly different (P > 0.05, t-test) to the response to LPS injection when boiled water was administered instead of horn extract. The known antipyretic indomethacin, however, at a dose of 10 mg/kg significantly reduced the response to LPS.
H P Laburn; D Mitchell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of basic and clinical physiology and pharmacology     Volume:  8     ISSN:  0792-6855     ISO Abbreviation:  J Basic Clin Physiol Pharmacol     Publication Date:  1997  
Date Detail:
Created Date:  1997-12-29     Completed Date:  1997-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9101750     Medline TA:  J Basic Clin Physiol Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Department of Physiology, University of the Witwatersrand Medical School, Parktown, South Africa.
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MeSH Terms
Analgesics, Non-Narcotic / therapeutic use*
Fever / chemically induced,  drug therapy*
Indomethacin / therapeutic use
Medicine, Chinese Traditional*
Polysaccharides, Bacterial
Salmonella typhi
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Polysaccharides, Bacterial; 53-86-1/Indomethacin

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