| Extraction and retention of technetium-99m Q12, technetium-99m sestamibi, and thallium-201 in isolated rat heart during coronary acidemia. | |
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MedLine Citation:
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PMID: 9391182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Technetium-99m Q12 and 99mTc-sestamibi are cationic lipophilic myocardial perfusion imaging tracers. Because myocardium in areas of ischemia becomes acidotic, experiments were designed to differentiate the effects of myocardial perfusate pH on radiotracer extraction and retention independent of substrate availability. We hypothesized that 99mTc-Q12 and 99mTc-sestamibi single-pass uptake and retention would be unaffected by a modest reduction in coronary perfusate pH. Isolated rat hearts were perfused at constant flow with Krebs-Henseleit buffer enriched with bovine red blood cells (20%). The indicator dilution method was used to measure the maximum extraction (Emax) and net extraction (Enet) of thallium-201 and 99mTc-Q12 (n = 8) or 201Tl and 99mTc sestamibi (n = 7) during baseline perfusion (pH = 7.4), during acidemic (pH = 6.7) perfusion, and during a restitution period with normal perfusate (pH = 7.4). 201Tl Emax (0.71+/-0.03) was greater than either 99mTc-Q12 or 99mTc-sestamibi Emax (0.27+/-0.02 and 0.26+/-0.01 respectively, P<0.0001). Acidemia significantly reduced 201Tl Emax (0.65+/-0.03, P<0.02) but not 99mTc-Q12 or 99mTc-sestamibi Emax (0.25+/-0.02 and 0.24+/-0.02 respectively). During control perfusion Enet of 201Tl was greater than that of 99mTc-Q12 at 3 and 5 min and greater than that of 99mTc-sestamibi at 3 min. 99mTc-Q12 Enet was less than 99mTc-sestamibi Enet at 3, 5, and 10 min. Acidemia decreased 201Tl and 99mTc-sestamibi Enet at 3, 5, and 10 min but had no effect on 99mTc-Q12 Enet. It is concluded that Emax of 99mTc-Q12 is less than that of 201Tl but is not different from that of 99mTc-sestamibi. Enet of 99mTc-Q12 is less than that of 99mTc-sestamibi. |
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Authors:
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A J McGoron; M C Gerson; D S Biniakiewicz; N J Roszell; L C Washburn; R W Millard |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 24 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-02-05 Completed Date: 1998-02-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1479-86 Citation Subset: IM |
Affiliation:
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E.L Saenger Radioisotope Laboratory, Division of Nuclear Medicine, Department of Radiology, University of Cincinnati College of Medicine, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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radionuclide imaging* Animals Cattle Furans / diagnostic use*, pharmacokinetics Heart / radionuclide imaging* Male Myocardial Ischemia / radionuclide imaging* Myocardium / metabolism Organotechnetium Compounds / diagnostic use*, pharmacokinetics Radioisotope Dilution Technique Radiopharmaceuticals / diagnostic use*, pharmacokinetics Rats Technetium Tc 99m Sestamibi / diagnostic use*, pharmacokinetics Thallium Radioisotopes / diagnostic use*, pharmacokinetics |
| Grant Support | |
ID/Acronym/Agency:
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HL07382/HL/NHLBI NIH HHS; HL07787-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Furans; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 0/technetium Tc 99m Q12; 109581-73-9/Technetium Tc 99m Sestamibi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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