| Extraction of acidic drugs from water and plasma: study of recovery with five different solvents. | |
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MedLine Citation:
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PMID: 6708473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The recovery of 28 acidic drugs from water and plasma was investigated spectrophotometrically using five different solvents for extraction: hexane, diethyl ether, toluene, n-butyl chloride, and chloroform. Nine barbiturates, three sulfonamides, four diuretics, and twelve other acidic drugs were studied. As classes, the barbiturates, the sulfonamides, and the diuretics were optimally extracted with diethyl ether from both water and plasma, while considerable variation in recovery was noted among solvents for the other drugs. In general, recoveries from water were higher than those from plasma with most solvents, except for the sulfonamides for which recoveries were often better from plasma. Extraction recoveries for the individual drugs are tabulated and compared. |
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Authors:
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D N Bailey; M Kelner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 8 ISSN: 0146-4760 ISO Abbreviation: J Anal Toxicol Publication Date: 1984 Jan-Feb |
Date Detail:
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Created Date: 1984-05-11 Completed Date: 1984-05-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 26-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Barbiturates
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isolation & purification Diuretics / isolation & purification Humans Pharmaceutical Preparations / blood, isolation & purification* Solvents Sulfonamides / isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Barbiturates; 0/Diuretics; 0/Pharmaceutical Preparations; 0/Solvents; 0/Sulfonamides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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