Document Detail


Extraction of acidic drugs from water and plasma: study of recovery with five different solvents.
MedLine Citation:
PMID:  6708473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The recovery of 28 acidic drugs from water and plasma was investigated spectrophotometrically using five different solvents for extraction: hexane, diethyl ether, toluene, n-butyl chloride, and chloroform. Nine barbiturates, three sulfonamides, four diuretics, and twelve other acidic drugs were studied. As classes, the barbiturates, the sulfonamides, and the diuretics were optimally extracted with diethyl ether from both water and plasma, while considerable variation in recovery was noted among solvents for the other drugs. In general, recoveries from water were higher than those from plasma with most solvents, except for the sulfonamides for which recoveries were often better from plasma. Extraction recoveries for the individual drugs are tabulated and compared.
Authors:
D N Bailey; M Kelner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  8     ISSN:  0146-4760     ISO Abbreviation:  J Anal Toxicol     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  26-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Barbiturates / isolation & purification
Diuretics / isolation & purification
Humans
Pharmaceutical Preparations / blood,  isolation & purification*
Solvents
Sulfonamides / isolation & purification
Chemical
Reg. No./Substance:
0/Barbiturates; 0/Diuretics; 0/Pharmaceutical Preparations; 0/Solvents; 0/Sulfonamides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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