| Extracting parametric images from dynamic contrast-enhanced MRI studies of the brain using factor analysis. | |
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MedLine Citation:
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PMID: 11231175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Factor analysis of dynamic studies (FADS) is a technique that allows structures with different temporal characteristics to be extracted from dynamic contrast enhanced studies without making any a priori assumptions about physiology. These dynamic structures may correspond to different tissue types or different organs or they may simply be a useful way of characterising the data. This paper describes a method of automatically extracting factor images and curves from contrast enhanced MRI studies of the brain. This method has been applied to 107 studies carried out on patients with acute stroke. The results show that FADS is able to extract factor curves correlated to arterial and venous signal intensity curves and that the corresponding factor images allow a distinction to be made between areas of the brain with normal and abnormal perfusion. The method is robust and can be applied routinely to dynamic studies of the brain. The constraints described are sufficiently general to be applicable to other dynamic MRI contrast enhanced studies where an increase in contrast concentration produces an increase in signal intensity. |
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Authors:
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A L Martel; A R Moody; S J Allder; G S Delay; P S Morgan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical image analysis Volume: 5 ISSN: 1361-8415 ISO Abbreviation: Med Image Anal Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-20 Completed Date: 2001-06-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9713490 Medline TA: Med Image Anal Country: England |
Other Details:
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Languages: eng Pagination: 29-39 Citation Subset: IM |
Affiliation:
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Department of Medical Physics, University Hospital, Queen's Medical Centre, Derby Rd., NG7 2UH, Nottingham, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebrovascular Circulation* Contrast Media Factor Analysis, Statistical Humans Image Processing, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Stroke / pathology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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