| An extract of the pleurotus ostreatus mushroom bolsters the glutathione redox system in various organs of aged rats. | |
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MedLine Citation:
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PMID: 20673055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study is to investigate the putative effect of an extract of the oyster mushroom, Pleurotus ostreatus, on reduced glutathione (GSH) and its metabolic enzymes in major organs of male albino rats. A significant (P < .05) decrease in the level of GSH was observed in liver, kidneys, heart, and brain of aged rats compared to young rats. Activities of glutathione S-transferase (GST), glutathione reductase (GR), and glucose 6-phosphate dehydrogenase (G6PDH) were significantly (P < .05) lower in the liver, kidneys, heart, and brain of aged rats. The isoform pattern of these enzymes in aged rats also revealed variations in relative concentrations, presumably due to oxidative stress during aging. Administration of the extract of P. ostreatus to aged rats resulted in a significant (P < .05) increase in the levels of GSH and elevated activities of GST, GR, and G6PDH in liver, kidney, heart, and brain tissues. An increased staining intensity of isoforms of GST and G6PDH was also noted in aged rats that had been treated with the mushroom extract compared to aged untreated rats. The results of this study may suggest that an extract of P. ostreatus, a potential antioxidant, can prevent the oxidation of GSH and protect its related enzymes during aging. |
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Authors:
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Thanasekaran Jayakumar; Philip Aloysius Thomas; Elango Ramesh; Pitchairaj Geraldine |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal food Volume: 13 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 771-8 Citation Subset: IM |
Affiliation:
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Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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drug effects*,
metabolism Animal Structures / drug effects, enzymology*, metabolism Animals Antioxidants / administration & dosage, isolation & purification Biological Factors / administration & dosage*, isolation & purification Brain / drug effects, enzymology, metabolism Glucosephosphate Dehydrogenase / metabolism Glutathione / metabolism* Glutathione Reductase / metabolism Glutathione Transferase / metabolism Heart / drug effects Kidney / drug effects, enzymology, metabolism Liver / drug effects, enzymology, metabolism Male Myocardium / enzymology, metabolism Oxidation-Reduction Pleurotus / chemistry* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Factors; 70-18-8/Glutathione; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 1.8.1.7/Glutathione Reductase; EC 2.5.1.18/Glutathione Transferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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