Document Detail


Extract of Aneilema keisak inhibits transforming growth factor-β-dependent signalling by inducing Smad2 downregulation in keloid fibroblasts.
MedLine Citation:
PMID:  23278899     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Keloids are characterised by the excessive accumulation of extracellular matrix (ECM), especially overabundant collagen formation. In keloid fibroblasts (KFs), transforming growth factor (TGF)-β-dependent signalling is closely associated with a variety of keloid pathologic responses such as ECM production and fibroblast overgrowth. Thus, inhibition of TGF-β signalling would be a potential therapeutic approach to prevent keloid scar formation. Thereby, we aimed to identify a novel TGF-β signalling blocker among natural products using a simplified screening approach. We discovered that the extract of Aneilema keisak (A.K-Ex) lowered TGF-β-dependent signalling by reducing Smad2 protein levels. Given that KFs showed altered dependency on TGF-β for survival and proliferation, A.K-Ex-mediated reduction in Smad2 protein levels significantly inhibited the major characteristics of KFs such as cell growth, migration and collagen synthesis, suggesting that A.K-Ex exhibits possible therapeutic activity on keloids.
Authors:
Won-Serk Kim; Ji-Seon Lee; Gab-Yong Bae; Jin-Ju Kim; Young-Won Chin; Young Yil Bahk; Hyung Geun Min; Hyuk-Jin Cha
Related Documents :
21220499 - Sorafenib inhibits the hepatocyte growth factor-mediated epithelial mesenchymal transit...
21318369 - Expression of the rice cdpk-7 in sorghum: molecular and phenotypic analyses.
24795769 - Effects of chaihu-shugan-san and shen-ling-bai-zhu-san on p38 mapk pathway in kupffer c...
24376679 - Combination of entner-doudoroff pathway with mep increases isoprene production in engin...
23840929 - A longitudinal study of caenorhabditis elegans larvae reveals a novel locomotion switch...
23268839 - Zmcpk11 is involved in abscisic acid-induced antioxidant defence and functions upstream...
8786839 - Phosphatidic acid activation of protein kinase c in la-n-1 neuroblastoma cells.
19138669 - P38 and erk, but not jnk, are involved in copper-induced apoptosis in cultured cerebell...
14764579 - Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulm...
Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Experimental dermatology     Volume:  22     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  69-71     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Affiliation:
Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effects of Sophora angustifolia and other natural plant extracts on melanogenesis and melanin tr...
Next Document:  Tensile stimuli increase nerve growth factor in human dermal fibroblasts independent of tension-indu...