| Extract of Aneilema keisak inhibits transforming growth factor-β-dependent signalling by inducing Smad2 downregulation in keloid fibroblasts. | |
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MedLine Citation:
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PMID: 23278899 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Keloids are characterised by the excessive accumulation of extracellular matrix (ECM), especially overabundant collagen formation. In keloid fibroblasts (KFs), transforming growth factor (TGF)-β-dependent signalling is closely associated with a variety of keloid pathologic responses such as ECM production and fibroblast overgrowth. Thus, inhibition of TGF-β signalling would be a potential therapeutic approach to prevent keloid scar formation. Thereby, we aimed to identify a novel TGF-β signalling blocker among natural products using a simplified screening approach. We discovered that the extract of Aneilema keisak (A.K-Ex) lowered TGF-β-dependent signalling by reducing Smad2 protein levels. Given that KFs showed altered dependency on TGF-β for survival and proliferation, A.K-Ex-mediated reduction in Smad2 protein levels significantly inhibited the major characteristics of KFs such as cell growth, migration and collagen synthesis, suggesting that A.K-Ex exhibits possible therapeutic activity on keloids. |
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Authors:
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Won-Serk Kim; Ji-Seon Lee; Gab-Yong Bae; Jin-Ju Kim; Young-Won Chin; Young Yil Bahk; Hyung Geun Min; Hyuk-Jin Cha |
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Publication Detail:
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Type: Letter |
Journal Detail:
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Title: Experimental dermatology Volume: 22 ISSN: 1600-0625 ISO Abbreviation: Exp. Dermatol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: Denmark |
Other Details:
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Languages: eng Pagination: 69-71 Citation Subset: IM |
Copyright Information:
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© 2013 John Wiley & Sons A/S. |
Affiliation:
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Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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