| Extracorporeal photopheresis and adjuvant aerosolized granulocyte-macrophage colony-stimulating factor for Sézary syndrome. | |
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MedLine Citation:
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PMID: 11838656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Encouraged by preliminary phase 1 studies of aerosolized granulocyte-macrophage colony-stimulating factor (GM-CSF, sargramostim) in the treatment of patients with melanoma and other malignancies, we treated a 72-year-old patient with Sézary syndrome, using alternate-week cycles of aerosolized GM-CSF in combination with monthly cycles of extracorporeal photopheresis (ECP). Sézary syndrome, one of the more aggressive forms of cutaneous T-cell lymphoma, is a devastating and highly symptomatic form of non-Hodgkin lymphoma in which malignant clones of mature helper CD4 T cells, containing large, convoluted nuclei known as Sézary cells, circulate in the blood and infiltrate skin. Extracorporeal photopheresis, an immunomodulatory therapy, has become a primary treatment for patients with Sézary syndrome. This pheresis-based therapy combines psoralen and ultraviolet A radiation as systemic photochemotherapy to induce immune responses. However, the activity and efficacy of ECP vary considerably. To our knowledge this is the first patient with Sézary syndrome treated with adjuvant aerosolized GM-CSF combined with ECP. It produced clinical improvement and decreased the number of circulating Sézary cells in a previously ECP-refractory patient. |
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Authors:
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Saskia A Bouwhuis; Svetomir N Markovic; Marian T McEvoy; Mark R Pittelkow |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Mayo Clinic proceedings. Mayo Clinic Volume: 77 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-12 Completed Date: 2002-02-27 Revised Date: 2007-10-29 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: United States |
Other Details:
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Languages: eng Pagination: 197-200 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Mayo Clinic, Rochester, Minn 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aerosols Aged Biopsy Blood Cell Count CD4-Positive T-Lymphocytes Combined Modality Therapy Granulocyte Macrophage Colony-Stimulating Factors, Recombinant / immunology, pharmacology, therapeutic use* Humans Middle Aged Photopheresis / methods* Prognosis Sezary Syndrome / blood, diagnosis, etiology, immunology, therapy* Skin Neoplasms / blood, diagnosis, etiology, immunology, therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Granulocyte Macrophage Colony-Stimulating Factors, Recombinant; 123774-72-1/sargramostim |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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