Document Detail

Extracorporeal perfusion of the whole human placenta--a new model.
MedLine Citation:
PMID:  6963967     Owner:  NLM     Status:  MEDLINE    
An extracorporeal dual perfusion system of the whole human placenta was developed using a technique of multiple blunt cannulations of the intervillous space. The system was evaluated according to various perfusion-dynamic, metabolic and morphological criteria. Angiographic and dye distribution studies showed 80 to 100 per cent perfusion of the placenta. The perfused organ consumed oxygen, utilized glucose and produced HCG. The flow rates and acid-base values were within acceptable limits. However, problems with high fetoplacental vascular resistance, tendency to metabolic acidosis and fetomaternal fluid transfer were encountered. Ultrastructural studies showed variations in the syncytiotrophoblast and the microvilli.
D Maulik; S F Contractor; J Lippes; A Knight
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Placenta. Supplement     Volume:  3     ISSN:  0265-7023     ISO Abbreviation:  Placenta Suppl     Publication Date:  1981  
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306308     Medline TA:  Placenta Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  353-65     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium
Glucose / metabolism
Models, Biological*
Oxygen / blood
Oxygen Consumption
Perfusion / methods*
Placenta / blood supply*,  metabolism
Reg. No./Substance:
50-99-7/Glucose; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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