| Extracorporeal perfusion of the swine uterus: effect of human seminal plasma. | |
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MedLine Citation:
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PMID: 21950778 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The active transport of sperm through the female genital tract is a very important factor in the fertilisation process. There is conflicting evidence as to whether seminal plasma has a positive or a negative effect on reproductive performance regarding the sperm transport in the female genital tract. In this study, we investigated if the perfused swine uterus is an appropriate model to study the effect of human seminal plasma on uterine contractility. It was found that repeated application of human seminal plasma caused a significantly higher rise in pressure and frequency of contractions in perfused swine uteri compared to buffer [a 1.8-fold and 1.5-fold pressure rise (Δt1SP, P = 0.025; Δt2SP, P = 0.004)] after the first and second application of seminal plasma respectively, and even a 2-fold pressure rise after the third application with a statistical significance of P = 0.007. The pressure rise caused by the seminal plasma over the entire period of application was calculated using a mathematical programme and was represented by the integral of the pressure curve over time. This perfusion model as well as the use of pressure-time integrals is suitable for patho-physiological studies of the uterus. |
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Authors:
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R Dittrich; J Henning; T Maltaris; I Hoffmann; P G Oppelt; S Cupisti; M W Beckmann; A Mueller; F Kiesewetter |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-26 |
Journal Detail:
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Title: Andrologia Volume: - ISSN: 1439-0271 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423506 Medline TA: Andrologia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Verlag GmbH. |
Affiliation:
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Department of Obstetrics and Gynaecology, University Hospital Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany Division of Andrology, Department of Dermatology, University Hospital Erlangen, University of Erlangen-Nuremberg, Erlangen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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