Document Detail

Extracorporeal membrane oxygenation for ARDS in adults.
MedLine Citation:
PMID:  22087681     Owner:  NLM     Status:  MEDLINE    
A 41-year-old woman presents with severe community-acquired pneumococcal pneumonia. Chest radiography reveals diffuse bilateral infiltrates, and hypoxemic respiratory failure develops despite appropriate antibiotic therapy. She is intubated and mechanical ventilation is initiated with a volume- and pressure-limited approach for the acute respiratory distress syndrome (ARDS). Over the ensuing 24 hours, her partial pressure of arterial oxygen (Pao2) decreases to 40 mm Hg, despite ventilatory support with a fraction of inspired oxygen (Fio2) of 1.0 and a positive end-expiratory pressure (PEEP) of 20 cm of water. She is placed in the prone position and a neuromuscular blocking agent is administered, without improvement in her Pao2. An intensive care specialist recommends the initiation of extracorporeal membrane oxygenation (ECMO).
Daniel Brodie; Matthew Bacchetta
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The New England journal of medicine     Volume:  365     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-17     Completed Date:  2011-12-07     Revised Date:  2012-02-09    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1905-14     Citation Subset:  AIM; IM    
Columbia University College of Physicians and Surgeons, and New York-Presbyterian Hospital, New York, NY 10032, USA.
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MeSH Terms
Anoxia / etiology,  therapy
Community-Acquired Infections / complications
Extracorporeal Membrane Oxygenation* / adverse effects,  methods
Pneumonia, Pneumococcal / complications
Practice Guidelines as Topic
Respiratory Distress Syndrome, Adult / etiology,  therapy*
Comment In:
N Engl J Med. 2012 Feb 9;366(6):575-6; author reply 576   [PMID:  22316467 ]
N Engl J Med. 2012 Feb 9;366(6):575; author reply 576   [PMID:  22316465 ]
N Engl J Med. 2012 Feb 9;366(6):575; author reply 576   [PMID:  22316466 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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