| Extracorporeal life support in a severe Taxus baccata poisoning. | |
| | |
MedLine Citation:
|
PMID: 20528617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: Yew (Taxus baccata) is a conifer known to be toxic since ancient times. Taxine A and taxine B, the toxic alkaloids of Taxus, block cardiac sodium and calcium channels causing nausea, vomiting, abdominal pain, cardiac arrhythmias, respiratory distress, coma, seizures, and death in yew poisoning. CASE REPORT: A 44-year-old male farmer was admitted to the hospital because of a suspected myocardial infarction. First bradycardia and then ventricular tachycardia were present and a severe right ventricular dilatation with biventricular dysfunction was observed but with normal coronary arteriography. He was resistant to conventional therapy and, 6 h after hospital admission, extracorporeal support with membrane oxygenation was applied. The patient recovered. Nine days later, a large number of yew leaves were unexpectedly observed in his feces. Botanical and laboratory analysis confirmed the poisoning. Blood (651 ng/mL) and urinary (5.6 mcg/mL) levels of 3,5-dimethoxyphenol (metabolite of taxicatine) were greater than previously reported in lethal cases. The patient was transferred to a psychiatric unit 17 days after admission. CONCLUSIONS: Intensive treatment of severe cardiovascular symptoms with antiarrhythmic drugs, temporary pacemaker, intra-aortic balloon pump, extracorporeal membrane oxygenation, and extracorporeal life support can be life-saving even after a potentially lethal ingestion of T. baccata leaves. |
| | |
Authors:
|
Claudia Panzeri; Giuseppe Bacis; Francesco Ferri; Gabriele Rinaldi; Andrea Persico; Francesca Uberti; Patrizia Restani |
Related Documents
:
|
10384187 - Myocardial substrate uptake and oxidation during and after routine cardiac surgery. 19829177 - Hyperbaric oxygen: its application in cardiology: a historical perspective and personal... 618627 - Effect of dopamine on hemodynamics and myocardial metabolism in shock following acute m... 15616397 - Targeted resuscitation strategies after injury. 10918647 - Interventional therapy in heart failure management. 1720537 - Control of refractory ventricular tachycardia with biventricular assist devices. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Clinical toxicology (Philadelphia, Pa.) Volume: 48 ISSN: 1556-9519 ISO Abbreviation: Clin Toxicol (Phila) Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-30 Completed Date: 2010-07-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101241654 Medline TA: Clin Toxicol (Phila) Country: England |
Other Details:
|
Languages: eng Pagination: 463-5 Citation Subset: AIM; IM |
Affiliation:
|
Bergamo Poison Control Center, Ospedali Riuniti, Bergamo, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alkaloids / diagnostic use, poisoning* Anti-Arrhythmia Agents / diagnostic use, poisoning Bradycardia / complications Extracorporeal Membrane Oxygenation / adverse effects Foodborne Diseases Heart-Assist Devices / adverse effects Humans Male Phloroglucinol / analogs & derivatives Plant Leaves / poisoning Plant Poisoning / diagnosis*, etiology, therapy* Seizures / complications Tachycardia, Ventricular / complications Taxaceae Taxoids Taxus / poisoning* |
| Chemical | |
Reg. No./Substance:
|
0/Alkaloids; 0/Anti-Arrhythmia Agents; 0/Taxoids; 108-73-6/Phloroglucinol; 12607-93-1/taxine; 500-99-2/phloroglucinol dimethyl ether |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Monoolein cubic phase containing acidic proteinoid: pH-dependent release.
Next Document: Liquid calcium fertilizer intoxication.