Document Detail

Extracorporeal circulation with low systemic heparinization during lung transplantation.
MedLine Citation:
PMID:  16757296     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Some lung transplantation (LT) recipients suffer from pulmonary hypertension and right ventricular dysfunction or failure requiring extracorporeal circulation (ECC) to avoid catastrophic complications during surgery. The extracorporeal support usually requires systemic heparinization which is potentially associated with important side effects. We performed eight LT using preheparinized ECC circuits and an oxygenator associated with a lower level of systemic heparinization without evidence of perioperative complications. PATIENTS AND METHODS: From May 2002 to May 2005, 8 patients (5 men and 3 women) of mean age 22.5 +/- 9.5 years underwent bilateral sequential lung transplantation (BSLT) for cystic fibrosis (n = 6) or idiopathic pulmonary fibrosis (n = 2). All procedures were performed with ECC through a femoro-femoral veno-arterial bypass with preheparinized circuits and an oxygenator. RESULTS: No intraoperative mortality occurred. The mean ECC time was 147.8 +/- 31.3 minutes and the mean heparin administered was 3525 +/- 969.16 UI. No coagulopathy or thrombotic events were observed perioperatively. CONCLUSIONS: Our study confirmed the efficacy and safety of prehepanized circuits and oxygenator for femoro-femoral veno-arterial bypass during LT for patients with severe pulmonary hypertension requiring ECC.
F Pugliese; F Ruberto; V Ferrazza; K Bruno; S Martelli; P Celli; S Perrella; G Aimi; D Diso; M Anile; F Venuta; G F Coloni; P Pietropaoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  38     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-07     Completed Date:  2006-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1167-8     Citation Subset:  IM    
Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Italia.
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MeSH Terms
Anticoagulants / therapeutic use
Cystic Fibrosis / surgery
Extracorporeal Circulation / methods*
Functional Laterality
Heparin / therapeutic use
Intraoperative Care*
Lung Transplantation*
Pulmonary Fibrosis / surgery
Retrospective Studies
Reg. No./Substance:
0/Anticoagulants; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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