| Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs. | |
| | |
MedLine Citation:
|
PMID: 17627190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We have recently demonstrated that low-energy extracorporeal shock wave therapy improves chronic myocardial ischemia in pigs and humans. In this study, we examined whether our shock wave therapy is also effective at improving left ventricular remodeling after acute myocardial infarction in pigs. METHODS: Acute myocardial infarction was created by surgically excising the proximal segment of the left circumflex coronary artery (n=20). In the early treatment protocol, the shock wave therapy was started 3 days after acute myocardial infarction, whereas in the late treatment protocol, the therapy was started 4 weeks after acute myocardial infarction (n=5 each). The remaining animals were treated in the same manner, but without the shock wave treatment in each protocol (n=5 each). RESULTS: In the early treatment protocol, left ventricular ejection fraction was higher (42+/-1 vs. 32+/-1%, P<0.001) and left ventricular end-diastolic volume was smaller (95+/-1 vs. 99+/-2 ml, P<0.05) in the shock wave group compared with the control group. Furthermore, wall thickening fraction (32+/-1 vs. 28+/-1%, P<0.01), regional myocardial blood flow (1.7+/-0.2 vs. 1.0+/-0.1 ml/min/g, P<0.01), and number of capillaries in the border zone (1348+/-15 vs. 938+/-34 mm2, P<0.0001) were all significantly improved in the shock wave group compared with the control group. By contrast, in the late treatment group, no such beneficial effects of the shock wave therapy were noted. CONCLUSION: These results suggest that our extracorporeal cardiac shock wave therapy is also an effective and noninvasive therapy for improving left ventricular remodeling after acute myocardial infarction when started in the early phase of the disorder. |
| | |
Authors:
|
Toyokazu Uwatoku; Kenta Ito; Kohtaro Abe; Keiji Oi; Takatoshi Hizume; Kenji Sunagawa; Hiroaki Shimokawa |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Coronary artery disease Volume: 18 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-07-13 Completed Date: 2007-10-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: England |
Other Details:
|
Languages: eng Pagination: 397-404 Citation Subset: IM |
Affiliation:
|
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Coronary Angiography Coronary Circulation Disease Models, Animal Echocardiography Gated Blood-Pool Imaging High-Energy Shock Waves / therapeutic use* Male Myocardial Infarction / diagnosis, physiopathology, radiotherapy* Severity of Illness Index Swine Treatment Outcome Ventricular Function, Left / physiology* Ventricular Remodeling / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum YKL-40 levels in patients with coronary artery disease.
Next Document: On rendering continuous glucose monitoring ready for prime time in the cardiac care unit.